Short and long-term outcomes between laparoscopic and open total gastrectomy for advanced gastric cancer after neoadjuvant chemotherapy

Table 8 Univariate and multivariate analyses for disease-free survival

Factor	Univariate analysis		P value	Multivariate analysis		P value
	HR	95%CI		HR	95%CI
Sex			0.259
Male	1.000
Female	0.851	0.642-1.127
Age			0.267
< 65	1.000
≥ 65	1.326	0.806-2.181
BMI (kg/m2)			0.706
< 25	1.000
≥ 25	0.706	0.403-1.237
Surgical approach			0.825
Laparoscopy	1.000
Open	0.947	0.582-1.539
CCI score			0.707
0-2	1.000
≥ 2	1.104	0.660-1.847
pTNM stage			0.000			0.022
0-II	1.000			1.000
III-IV	2.418	1.471-3.973		1.854	1.095-3.140
Tumor diameter (cm)			0.022			0.200
≤ 3	1.000			1.000
> 3	1.954	1.100-3.470		1.484	0.812-2.710
Operation time (min)			0.710
≤ 240	1.000
> 240	1.095	0.679-1.765
Estimated blood loss (mL)			0.024			0.204
≤ 200	1.000			1.000
> 200	1.730	1.075-2.785		1.379	0.840-2.263
Vascular invasion			0.001			0.020
No	1.000			1.000
Yes	2.245	1.378-3.659		1.824	1.101-3.022
Nerve invasion			0.203
No	1.000
Yes	1.387	0.838-2.295
Differentiation			0.283
Well/moderate	1.000
Poor/undifferentiated	1.311	0.800-2.148
Complications			0.751
No	1.000
Yes	1.093	0.631-1.894
Historical factor			0.691
2012-2015	1.000
2016-2019	1.102	0.683-1.779

HR: Hazard ratio; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; CCI: Comprehensive complication index; BMI: Body mass index.