Short and long-term outcomes between laparoscopic and open total gastrectomy for advanced gastric cancer after neoadjuvant chemotherapy

Table 7 Univariate and multivariate analyses for overall survival

Factor	Univariate analysis		P value	Multivariate analysis		P value
	HR	95%CI		HR	95%CI
Sex			0.127
Male	1.000
Female	1.541	0.885-2.684
Age			0.647
< 65	1.000
≥ 65	1.129	0.671-1.900
BMI (kg/m2)			0.091			0.049
< 25	1.000			1.000
≥ 25	0.601	0.333-1.086		0.547	0.300-0.998
Surgical approach			0.549
Laparoscopy	1.000
Open	1.164	0.708-1.914
CCI score			0.438
0-2	1.000
≥ 2	1.225	0.733-2.049
pTNM stage			0.000			0.006
0-II	1.000			1.000
III-IV	2.632	1.569-4.413		2.224	1.258-3.930
Tumor diameter (cm)			0.039			0.153
≤ 3	1.000			1.000
> 3	1.838	1.031-3.277		1.577	0.844-2.945
Operation time (min)			0.483
≤ 240	1.000
> 240	1.192	0.730-1.948
Estimated blood loss (mL)			0.074			0.588
≤ 200	1.000			1.000
> 200	1.559	0.958-2.536		1.154	0.688-1.935
Vascular invasion			0.008			0.062
No	1.000			1.000
Yes	1.987	1.200-3.289		1.712	0.974-3.010
Nerve invasion			0.079			0.567
No	1.000			1.000
Yes	1.580	0.949-2.632		0.838	0.456-1.537
Differentiation			0.261
Well/moderate	1.000
Poor/undifferentiated	1.335	0.806-2.212
Complications			0.662
No	1.000
Yes	1.131	0.651-1.968
Historical factor			0.861
2012-2015	1.000
2016-2019	0.957	0.587-1.560

HR: Hazard ratio; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; CCI: Comprehensive complication index; BMI: Body mass index.