Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy: A propensity score matching analysis

Table 5 Univariate and multivariate analysis of overall survival after propensity score matching

Variables	Univariate analysis			Multivariate analysis
	Hazard ratio	95%CI	P value	Hazard ratio	95%CI	P value
Age (yr): < 60 vs ≥ 60	0.806	0.491-1.323	0.393
Sex: Female vs Male	1.244	0.711-2.177	0.444
ASA: 1-2 vs 3	0.978	0.355-2.696	0.965
Surgery: LTG vs OTG	0.729	0.446-1.192	0.207
BMI: < 28 vs ≥ 28	1.608	0.504-5.133	0.422
Differentiation: Well/moderate vs Poor	0.713	0.416-1.224	0.220
ypT stage: T0-3 vs T4	0.446	0.267-0.746	0.002	0.520	0.308-0.877	0.014
ypN stage: N0 vs N1-3	0.401	0.217-0.741	0.004	0.431	0.227-0.821	0.010
Metastasis: M0 vs M1	0.425	0.152-1.188	0.103	0.529	0.185-1.510	0.234
Nerve invasion: Yes vs No	1.601	0.973-2.635	0.064	0.930	0.531-1.628	0.799
Lymph-vascular invasion: Yes vs No	2.046	1.236-3.388	0.005	1.155	0.623-2.140	0.647
Mandard TRG: ≤ 3 vs > 3	0.510	0.312-0.833	0.007	0.666	0.390-1.136	0.136
Postoperative complication: Yes vs No	0.635	0.338-1.193	0.158
Type of NAT: NAC vs NCRT	2.248	0.900-5.619	0.083	1.647	0.619-4.382	0.317
Resection: R0 vs R1/R2	0.385	0.120-1.237	0.109	0.357	0.110-1.154	0.085

LTG: Laparoscopic total gastrectomy; OTG: Open total gastrectomy; CI: Confidence interval; ASA: American Society of Anesthesiologist; BMI: Body mass index; TRG: Tumor regression grading; NAT: Neoadjuvant therapy; NAC: Neoadjuvant chemotherapy; NCRT: Neoadjuvant chemoradiotherapy.