Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum

Table 1 Comparative analysis of clinicopathological factors between patients with resected cancer of the second portion of the duodenum and ampullary carcinoma

Variable	Comparison	DC-II (n = 27), %		AC (n = 80)	P value
Sex	Male	15 (55.6)	49 (61.3)	0.65
	Female	12 (44.4)	31 (38.7)
Age	Median (range)	69 (41-85)	64 (37-84)	0.35
Preoperative BMI (kg/m2)	Median (range)	22.1 (16.9-27.3)	21.7 (15.8-31.3)	0.59
Preoperative mGPS	0	17	47	-
	1	5	18	-
	2	5	14	-
	0	17 (63.0)	47 (58.8)	0.82
	1-2	10 (37.0)	32 (40.0)
Preoperative biliary drainage	No	21 (77.8)	44 (55.0)	0.042
	Yes	6 (22.2)	36 (45.0)
Preoperative symptoms	Absent	8 (29.6)	31 (38.7)	0.49
	Present	19 (70.4)	49 (61.3)
Digestive symptoms	Absent	13 (48.1)	60 (75.0)	0.0158
	Present	14 (51.9)	20 (25.0)
Anemia or tarry stool	Absent	23 (85.2)	77 (96.3)	0.06
	Present	4 (14.8)	3 (3.7)
Preoperative CA19-9 (U/mL)	Normal	19 (70.4)	56 (70.0)	1
	Elevated	8 (29.6)	24 (30.0)
Preoperative CEA (ng/mL)	Normal	25 (92.6)	66 (82.5)	0.35
	Elevated	2 (7.4)	13 (16.3)
Surgery	PD	12	38	-
	SSPPD	14	35	-
	PpPD	1	7	-
Operation time (min)	Median (range)	451 (287-837)	446.5 (266-736)	0.44
Intraoperative blood loss volume (mL)	Median (range)	685 (80-4110)	652 (150-9015)	0.48
Gross appearance	Protruding type	8 (29.6)	59 (73.8)	< 0.0001
	Ulcerative-type	19 (70.4)	21 (26.2)
Histological grade	Pap	1	3	-
	Well	10	42	-
	Mod	13	31	-
	Por	1	4	-
	Muc	2	0	-
	Pap/well	11 (40.7)	45 (56.3)	0.19
	Mod/por/muc	16 (59.3)	35 (43.7)
Tumor diameter (mm)	Median (range)	35 (14-65)	18 (5-84)	< 0.0001
T category1	Tis	5	23	-
	T1 (1a, 1b)	5 (4, 1)	9	-
	T2	1	28	-
	T3	5	16	-
	T4	11	4	-
	T0–T2	11 (40.7)	60 (75.0)	0.0019
	T3–T4	16 (59.3)	20 (25.0)
N factor	N0	16	58	-
	N1	5	22	-
	N2	6	x	-
Lymph node metastasis	Absent	16 (59.3)	58 (72.5)	0.23
	Present	11 (40.7)	22 (27.5)
Number of lymph nodes with metastasis	Median (range)	0 (0–6)	0 (0–12)	0.13
M factor	M0	24	78	0.1
	M1	3	2	-
Stage	0	5	22	-
	I (A, B)	6	29 (11, 18)	-
	II A	2	4	-
	II B	3	19	-
	III (A, B)	8 (5, 3)	4	-
	IV	3	2	-
Lymphatic invasion	0	15	50	-
	1	4	12	-
	2	7	15	-
	3	1	2	-
	X	0	1	-
	0	15 (55.6)	50 (62.5)	0.5
	1-3	12 (44.4)	29 (36.3)
Venous invasion	0	20	69	-
	1	5	8	-
	2	2	2	-
	3	0	0	-
	X	0	1	-
	0	20 (74.1)	69 (86.3)	0.13
	1-3	7 (25.9)	10 (12.5)
Postoperative complication (≥ CD III)	No	18 (66.7)	42 (52.5)	0.26
	Yes	9 (33.3)	38 (47.5)
Adjuvant chemotherapy	No	19 (70.4)	55 (68.8)	1
	Yes	8 (29.6)	25 (31.2)

¹7^th edition of the Union for International Cancer Control TNM classification.

AC: Ampullary carcinoma; BMI: Body mass index; CA19-9: Carbohydrate antigen 19-9; CD: Clavien–Dindo classification; CEA: Carcinoembryonic antigen; DC-II: Carcinoma of the second portion of the duodenum; mGPS: Modified Glasgow prognostic score; mod: moderately differentiated adenocarcinoma; muc: mucinous adenocarcinoma; pap: papillary adenocarcinoma; PD: Pancreaticoduodenectomy; poor: Poorly differentiated adenocarcinoma; PpPD: Pylorus-preserving pancreaticoduodenectomy; SSPPD: Subtotal stomach-preserving pancreatoduodenectomy; well: Well-differentiated adenocarcinoma.