Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought

Table 4 Predictive value of laboratory variables for hospital mortality in acute necrotizing pancreatitis patients

Variables	Cutoff	Sensitivity	Specificity	AUC	95%CI	PPV	NPV	P value
AST (E), μkat/L	> 0.53	33.3%	92.0%	0.727	0.547-0.865	60.0%	79.3%	0.016
α-amylase (E), U/L	≤ 17.2	66.7%	84.0%	0.729	0.550-0.866	60.0%	87.5%	< 0.032
DB (E), μmol/L	> 4.2	44.4%	100.0%	0.782	0.608-0.905	100.0%	83.3%	< 0.001
DB(A/E)	≤ 1	22.2%	95.8%	0.764	0.584-0.894	66.7%	76.7%	0.0015

A: Day 1 (on admission); E: Day before the operative pancreatic debridement. ANP: Acute necrotizing pancreatitis; AST: Aspartate aminotransferase; AUC: area under the curve; CI: Confidential intervals; DB: Direct bilirubin; NPV: negative predictive values; PPV: positive predictive values.