Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer

Table 3 Predictors for overall survival on univariate and multivariate analyses

	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Male (vs female)	0.71 (0.34–1.49)	0.365
Age (per 1 year increase)	1.06 (1.02-1.09)	0.004	1.05 (1.01-1.08)	0.014
SCC (vs AC)	2.06 (1.02-4.16)	0.045	1.20 (0.50-2.87)	0.674
Neoadjuvant + (vs neoadjuvant-)	2.22 (1.11-4.44)	0.025	1.61 (0.72-3.58)	0.244
Adjuvant + (vs adjuvant-)	1.76 (0.86-3.62)	0.122
Transthoracic approach (vs transhiatal approach)	1.64 (0.83-3.22)	0.148
pStage III/IV (vs pStage I/II)	9.55 (3.68-24.76)	< 0.001	7.14 (2.67-19.13)	< 0.001
R1 (vs R0)	2.62 (1.08-6.35)	0.033	1.79 (0.69-4.68)	0.232
Anastomotic leakage	3.07 (1.07-8.80)	0.037	3.59 (1.11-11.58)	0.032
Postoperative pneumonia	1.68 (0.59-4.78)	0.332

P: Pathologic; SCC: Squamous cell carcinoma; AC: Adenocarcinoma; R0: No residual tumor; R1: Microscopic residual tumor; HR: Hazard ratio.