Perioperative steroid administration reduces overall complications in patients undergoing liver resection: A meta-analysis

Table 3 Perioperative steroid protocols of included studies

Ref.	Study design	Country	Steroid protocol	Control protocol
Donadon et al[13], 2016	RCT	Italy	Preoperative bolus infusion (5%) of 500 mg methylprednisolone in 250 mL glucose for 1 h prior to hepatectomy, then continuous infusion for 6 h	250 mL glucose-5% as bolus and subsequent continuous infusion
Hasegawa et al[15], 2020	RCT	Japan	Preoperative, up to 500 mg methylprednisolone in saline solution	Saline only
Hayashi et al[12], 2011	RCT	Japan	Intraoperative 500 mg hydrocortisone immediately prior to hepatic-pedicle clamping 300 mg hydrocortisone on POD1 200 mg on POD 2, 100 mg on POD3	0
Muratore et al[20], 2003	RCT	Italy	Preoperative (30 min before surgery) 30 mg/kg per body weight IV methylprednisolone	0
Pulitanòet al[17], 2007	RCT	Italy	Preoperative 500 mg methylprednisolone	0
Schmidt et al[18], 2007	RCT	Germany	Preoperative (90 min before surgery) 30 mg/kg per body weight IV methylprednisolone	50 mL IV saline
Yamashita et al[16], 2001	RCT	Japan	Preoperative (2 h before surgery) 500 mg IV methylprednisolone	0
Zi et al[19], 2015	RCT	China	Intraoperative 500 mg methylprednisolone prior to liver resection	Hepatectomy only

RCT: Randomized controlled trial; IV: Intravenous; POD: Postoperative day.