Genitourinary function and defecation after colorectal cancer surgery with low- and high-ligation of the inferior mesenteric artery: A meta-analysis

Table 3 Endpoints of this meta-analysis

Endpoint	No. of patients	No. of studies	LL	HL	OR WMD (95CI)	I2(%)	P value
Functional outcomes
Urinary dysfunction	2029	7	1093	936	OR, 1.23 (0.95-1.59)	25	0.12
Urinary retention	1050	4	301	749	OR, 1.51 (0.85-2.68)	0	0.16
Urinary infection	1617	3	633	984	OR, 0.29 (0.16-0.54)	0	< 0.0001
Genitourinary dysfunction	458	2	212	246	OR, 0.32 (0.17-0.61)	0	0.0006
Nocturnal bowel movement	884	3	461	423	OR, 0.73 (0.55-0,97)	0	0.03
Need for antidiarrheal or laxative drugs	187	2	94	93	OR, 0.70 (0.37-1.30)	14	0.26
Wexner’s incontinence score	274	3	138	136	MD, -0.01 (-0.71-0.70)	76	0.99
Safety outcomes
Anastomotic leakage	4574	13	1830	2744	OR, 0.69 (0.45-1.07)	50	0.10
Anastomotic stenosis	686	4	326	360	OR, 0.31 (0.16-0.62)	46	0.0009
Postoperative complication	2622	5	892	1730	OR, 1.07 (0.66-1.72)	62	0.79
Mortality	822	6	394	428	OR, 2.70 (0.64-11.40)	0	0.18
Operative time	2491	7	996	1495	MD, 4.42 (-2.05-10.89	80	0.18
Blood loss	2357	6	913	1444	MD, -0.63 (-4.01-2.76)	76	0.72
Oncological outcomes
Total lymph nodes harvested	2491	7	996	1495	MD, 0.68 (-1.03-2.38)	94	0.44
Recurrence	1340	8	706	634	OR, 0.97 (0.73-1.30)	0	0.85
5-year overall survival	2821	7	1035	1786	OR, 0.94 (0.61-1.44)	61	0.77
5-year disease-free survival	1523	5	602	921	OR, 0.86 (0.65-1.14)	0	0.29

LL: Low ligation; HL: High ligation; WMD: Weighted mean difference.