Advances in endoscopic therapy using grasping-type scissors forceps (with video)

Table 3 Reported comparison studies of the clinical outcomes of endoscopic submucosal dissection using the clutch cutter vs using conventional knives

Organ	Ref.		ESD using the clutch cutter	ESD using the conventional knives	P value
Esophagus	Esaki et al[19], 2020	Type of knife	-	IT-KN, DK, FK, SMK	-
		Number of patients1	36	36	-
		Median procedure time (min)	44	66.5	0.02
		En-bloc resection rate (%)	100	97.2	1
		R0 resection rate (%)	88.9	86.1	1
		Perforation rate (%)	0	5.6	0.20
		Delayed bleeding rate (%)	0	0	-
Stomach	Nagai et al[21], 2016	Type of knife	-	IT-2K	-
		Number of patients	56	61	-
		Median procedure time (min)	66	41	0.04
		En-bloc resection rate (%)	93	98	0.195
		R0 resection rate (%)	ND	ND	-
		Perforation rate (%)	3.6	1.6	-
		Delayed bleeding rate (%)	3.6	1.6	-
Stomach	Hayashi et al[22], 2018	Type of knife	-	IT-2K,SMK	-
		Number of patients1	44	44	-
		Median procedure time (min)	49	88.5	<0.001
		En-bloc resection rate (%)	100	100	-
		R0 resection rate (%)	100	100	-
		Perforation rate (%)	0	0	-
		Delayed bleeding rate (%)	2.3	6.8	0.620
Stomach	Dohi et al[23], 2019	Type of knife	-	IT-2K	-
		Number of patients1	61	61	-
		Median procedure time (min)	44	56	0.005
		En-bloc resection rate (%)	100	100	1
		R0 resection rate (%)	93.4	100	0.06
		Perforation rate (%)	0	4.9	0.12
		Delayed bleeding rate (%)	0	6.6	0.06
Duodenum	Dohi et al[24], 2020	Type of knife	-	FK	-
		Number of patients	47	37	-
		Median procedure time (min)	36	54	0.045
		En-bloc resection rate (%)	100	94.6	0.191
		R0 resection rate (%)	97.9	83.8	0.04
		Intra-ESD perforation rate (%)	0	4.9	0.014
		Delayed perforation rate (%)	2.1	8.1	0.316
		Delayed bleeding rate (%)	4.2	0	0.501

¹A Propensity Score-Matched Analysis. ESD: Endoscopic submucosal dissection; ITKN: IT-knife nano; DK: Dual knife; FK: Flush knife; SMK: Splash M-knife; IT-K2: Insulated-tip knife-2; ND: Not described.