Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients

doi:10.4240/wjgs.v13.i7.689

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Jul 27, 2021; 13(7): 689-701
Published online Jul 27, 2021. doi: 10.4240/wjgs.v13.i7.689

Table 5 Association between lipoprotein-cholesterol-apolipoprotein score with overall survival and progression-free survival in patients with colorectal cancer among different subgroups

		LA score
		PFS			OS
		n	Progression	HR (95%CI)	n	Death	HR (95%CI)
Age (yr)	< 65	330	90	0.725 (0.532-0.987)	330	49	0.626 (0.424-0.924)
Age (yr)	≥ 65	191	58	0.540 (0.358-0.814)	191	38	0.724 (0.437-1.199)
Sex	Male	321	97	0.671 (0.500-0.901)	321	58	0.756 (0.520-1.101)
Sex	Female	200	51	0.592 (0.366-0.956)	200	29	0.572 (0.333-0.981)
TNM stage	I/II	243	35	0.805 (0.421-1.538)	243	15	0.678 (0.265-1.735)
TNM stage	III/IV	278	113	0.632 (0.485-0.824)	278	72	0.676 (0.490-0.932)
Tumor location	Colon	320	91	0.793 (0.557-1.128)	320	53	0.686 (0.454-1.036)
Tumor location	Rectum	201	57	0.582 (0.411-0.826)	201	34	0.710 (0.450-1.121)
Tumor size (cm)	d < 2	12	2	0	12	2	0
	2 ≤ d < 5	374	108	0.575 (0.435-0.761)	374	61	0.636 (0.445-0.908)
	d ≥ 5	135	38	0.792 (0.485-1.294)	135	24	0.634 (0.354-1.137)
Differentiation	Low	56	18	0.504 (0.286-0.890)	56	11	0.298 (0.149-0.594)
	Medium	415	118	0.722 (0.534-0.977)	415	68	0.781 (0.528-1.155)
	High	50	12	0.534 (0.261-1.093)	50	8	0.704 (0.313-1.586)

LA: Lipoprotein cholesterol-apolipoprotein; PFS: Progression-free survival; OS: Overall survival; HR: Hazard Ratio; CI: Confidence interval.

Citation: Gu JN, Yao S, Cao YH, Deng SH, Mao FW, Jiang HY, He YT, Li XY, Ke SQ, Li HL, Li H, Liu XH, Liu HL, Wang JL, Wu K, Liu L, Cai KL. Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients. World J Gastrointest Surg 2021; 13(7): 689-701
URL: https://www.wjgnet.com/1948-9366/full/v13/i7/689.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i7.689