Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients

Table 4 Cox proportional hazards regression analyses for lipoprotein-cholesterol-apolipoprotein score for progression-free survival and overall survival

	Continuous variable
	PFS
	Univariate	P value	Multivariate1	P value
	HR (95%CI)		HR (95%CI)
LA score3	0.625 (0.490-0.797)	< 0.001b	0.654 (0.512-0.836)	0.001a
	OS
	Univariate	P value	Multivariate2	P value
	HR (95%CI)		HR (95%CI)
LA score3	0.616 (0.453-0.838)	0.002b	0.677 (0.500-0.917)	0.012a
	Dummy variable
	PFS
	Univariate	P value	Multivariate1	P value
	HR (95%CI)		HR (95%CI)
LA score3 1	0.598 (0.280-1.277)	0.184	0.646 (0.302-1.383)	0.261
LA score3 2	0.387 (0.233-0.643)	< 0.001b	0.427 (0.256-0.713)	0.001a
	OS
	Univariate	P value	Multivariate2	P value
	HR (95%CI)		HR (95%CI)
LA score3 1	0.973 (0.370-2.561)	0.956	1.508 (0.507-3.992)	0.408
LA score3 2	0.413 (0.213-0.802)	0.009b	0.524 (0.269-1.019)	0.057

Binary classification (I/II vs III/IV) of tumor node metastasis (TNM) stage was adopted.

¹(Progression-free survival) Multivariate analysis adjusted for age, TNM stage, vascular tumor thrombus, chemotherapy, and radiotherapy. We used a stepwise regression approach for multivariate analysis.

²(Overall survival) Multivariate analysis adjusted for age, sex, TNM stage, and circumferential margin.

³This indicator combined ApoA1/ApoB and HDL-C/LDL-C. Per additional score was associated with a decreased risk of progression-free survival and overall survival in colorectal cancer patient.

^aStatistical significance is expressed as P < 0.05 (for multivariate analysis).

^bStatistical significance is expressed as P < 0.05 (for univariate analysis).

HR: Hazard ratio; 95%CI: 95% confidence interval; AUC: Area under the ROC curve; PFS: Progression-free survival; OS: Overall survival; LA: Lipoprotein cholesterol-apolipoprotein.