Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients

Table 3 Cox proportional hazards regression analyses for lipid-based indicators for progression-free survival and overall survival

	AUC	Cut-point	PFS
			Univariate	P value	Multivariate1	P value
			HR (95%CI)		HR (95%CI)
HDL-C/LDL-C	0.497	0.323	0.672 (0.500-0.904)	0.009b	0.710 (0.528-0.955)	0.024a
ApoA1/ApoB	0.528	0.909	0.465 (0.302-0.715)	0.001b	0.501 (0.324-0.775)	0.002a
			OS
	AUC	Cut-point	Univariate	P value	Multivariate2	P value
			HR (95%CI)		HR (95%CI)
HDL-C/LDL-C	0.506	0.323	0.573 (0.402-0.815)	0.002b	0.619 (0.434-0.882)	0.008a
ApoA1/ApoB	0.527	0.871	0.411 (0.232-0.729)	0.002b	0.481 (0.271-0.853)	0.012a

Binary classification (I/II vs III/IV) of tumor node metastasis (TNM) stage was adopted.

¹(Progression-free survival) Multivariate analysis adjusted for age, TNM stage, vascular tumor thrombus, chemotherapy, and radiotherapy. We used a stepwise regression approach for multivariate analysis.

²(Overall survival) Multivariate analysis adjusted for age, sex, TNM stage, and circumferential margin.

^aStatistical significance is expressed as P < 0.05 (for multivariate analysis).

^bStatistical significance is expressed as P <0.05 (for univariate analysis).

HR: Hazard ratio; 95%CI: 95% confidence interval; AUC: Area under the ROC Curve; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B; PFS: Progression-free survival; OS: Overall survival.