Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients

Table 2 Cox proportional hazards regression analyses for basic lipid indicators for progression-free survival and overall survival

	AUC	Cut-point	PFS
			Univariate	P value	Multivariate1	P value
			HR (95%CI)		HR (95%CI)
HDL-C (mmol/L)	0.519	0.920	0.699 (0.530-0.920)	0.011b	0.696 (0.528-0.918)	0.010a
LDL-C (mmol/L)	0.513	2.160	0.865 (0.679-1.103)	0.242	0.878 (0.689-1.119)	0.295
ApoA1 (G/L)	0.610	1.030	0.520 (0.374-0.725)	< 0.001b	0.617 (0.442-0.863)	0.005a
ApoB (G/L)	0.547	0.860	0.743 (0.537-1.029)	0.074	0.796 (0.574-1.103)	0.170
			OS
	AUC	Cut-point	Univariate	P value	Multivariate2	P value
			HR (95%CI)		HR (95%CI)
HDL-C (mmol/L)	0.519	0.900	0.492 (0.354-0.685)	< 0.001b	0.505 (0.363-0.702)	< 0.001a
LDL-C (mmol/L)	0.499	3.650	1.645 (1.096-2.468)	0.016b	1.503 (1.001-2.258)	0.050
ApoA1 (G/L)	0.578	1.130	0.572 (0.375-0.873)	0.010b	0.625 (0.410-0.955)	0.030a
ApoB (G/L)	0.527	0.860	0.744 (0.487-1.136)	0.171	0.807 (0.528-1.234)	0.323

Binary classification (I/II vs III/IV) of tumor node metastasis (TNM) stage was adopted.

¹(Progression-free survival) Multivariate analysis adjusted for age, TNM stage, vascular tumor thrombus, chemotherapy, and radiotherapy. We used a stepwise regression approach for multivariate analysis.

²(Overall survival) Multivariate analysis adjusted for age, sex, TNM stage, and circumferential margin.

^aStatistical significance is expressed as P < 0.05 (for multivariate analysis).

^bStatistical significance is expressed as P < 0.05 (for univariate analysis).

HR: Hazard ratio; 95%CI: 95% confidence interval; AUC: Area under the ROC curve; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B; TNM: Tumor node metastasis; PFS: Progression-free survival; OS: Overall survival.