Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients

Table 1 Baseline patient clinicopathologic characteristics

		Progression-free survival		1P value	Overall survival		1P value
		No progression	Progression		Survival	Death
		(n = 1388) (%)	(n = 308) (%)		(n = 1494) (%)	(n = 202) (%)
Age (yr) (mean ± SD)		58.61 ± 11.71	58.48 ± 12.64	0.861	58.64 ± 11.75	58.19 ± 12.81	0.618
Sex	Male	821 (59.15)	195 (63.31)	0.199	880 (58.90)	136 (67.33)	0.022
	Female	567 (40.85)	113 (36.69)		614 (41.10)	66 (32.67)
Tumor location	Colon	801 (57.71)	178 (57.79)	0.999	861 (57.63)	118 (58.42)	0.880
	Rectum	587 (42.29)	130 (42.21)		633 (42.37)	84 (41.58)
TNM stage	I	216 (15.56)	7 (2.27)	< 0.001	219 (14.66)	4 (1.98)	< 0.001
	II	522 (37.61)	51 (16.56)		536 (35.88)	37 (18.32)
	III	561 (40.42)	93 (30.19)		570 (38.15)	84 (41.58)
	IV	89 (6.41)	157 (50.97)		169 (11.31)	77 (38.12)
Tumor size (cm)	d < 2	61 (4.39)	12 (3.90)	0.863	67 (4.48)	6 (2.97)	0.246
	2 ≤ d < 5	886 (63.83)	201 (65.26)		964 (64.52)	123 (60.89)
	d > 5	441 (31.77)	95 (30.84)		463 (31.00)	73 (36.14)
Differentiation	Low	186 (13.40)	36 (11.69)	0.586	192 (12.85)	30 (14.85)	0.648
	Medium	1104 (79.54)	253 (82.14)		1197 (80.12)	160 (79.21)
	High	98 (7.06)	19 (6.17)		105 (7.03)	12 (5.94)
Circumferential margin	No	1372 (98.85)	301 (97.73)	0.167	1477 (98.86)	196 (97.03)	0.047
	Yes	16 (1.15)	7 (2.27)		17 (1.14)	6 (2.97)
Vascular tumor thrombus	No	1111 (80.04)	218 (70.78)	0.001	1180 (78.98)	149 (73.76)	0.101
	Yes	277 (19.96)	90 (29.22)		314 (21.02)	53 (26.24)
Nerve invasion	No	1098 (79.11)	228 (74.03)	0.057	1177 (78.78)	149 (73.76)	0.122
	Yes	290 (20.89)	80 (25.97)		317 (21.22)	53 (26.24)
Chemotherapy	No	606 (43.66)	87 (28.25)	< 0.001	603 (40.36)	90 (44.55)	0.254
	Yes	782 (56.34)	221 (71.75)		891 (59.64)	112 (55.45)
Radiotherapy	No	1315 (94.74)	275 (89.29)	0.001	1400 (93.71)	190 (94.06)	0.999
	Yes	73 (5.26)	33 (10.71)		94 (6.29)	12 (5.94)
ApoA1 (G/L)		1.22 ± 0.25	1.12 ± 0.27	< 0.001	1.20 ± 0.25	1.12 ± 0.28	0.010
ApoB (G/L)		0.94 ± 0.23	0.91 ± 0.24	0.170	0.93 ± 0.23	0.92 ± 0.25	0.628
HDL-C (mmol/L)		1.22 ± 0.33	1.20 ± 0.34	0.208	1.22 ± 0.33	1.20 ± 0.37	0.440
LDL-C (mmol/L)		2.62 ± 0.75	2.60 ± 0.84	0.807	2.61 ± 0.75	2.64 ± 0.90	0.664

¹P value was calculated by the Student’s t-test for continuous variables and the Chi-square test for categorical variables.

ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B; HDL-C: High-density lipoprotein-cholesterol; TNM: Tumor node metastasis; LDL-C: Low-density lipoprotein-cholesterol.