Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study

Figure 1 Flow diagram of the current study. Hepatocellular carcinoma (HCC) patients diagnosed from January 2004 to July 2015 were retrieved from the Chang Gung Research Database (CGRD; n = 32403). Two models were designed for analysis: model 1, patients with HCC ≥ 10 cm (L-HCC; 426 patients) or HCC < 10 cm (S-HCC; 3559 patients) receiving liver resection; model 2, patients with HCC ≥ 10 cm receiving either liver resection or transarterial chemoembolization (TACE; 361 patients) as the primary treatment. The primary outcome was overall survival (OS), while HCC-specific survival and disease-free survival (DFS) were the secondary outcomes.