Benign vs malignant pancreatic lesions: Molecular insights to an ongoing debate

Figure 6 Pancreatic mass biopsy showing a minute focus of atypical glandular structure, highly suspicious for carcinoma. A: The atypical glands are surrounded by desmoplastic stromal reaction (hematoxylin & eosin, 190 ×, scale 100 µm); B: The atypical glands retain SMAD4 expression; this staining pattern does not rule out malignancy (SMAD4, 190 ×, scale 100 µm).