Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study

Table 4 Analyses of survival outcome with and without IPTW between the two groups: HCC ≥ 10 cm vs < 10 cm

	Without IPTW				With IPTW
	Unadjusted		Adjusted		Unadjusted		Adjusted
	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Recurrence
Entire cohort	2.24 (1.96-2.56)	< 0.001	1.85 (1.60-2.13)	< 0.001	1.60 (1.28-2.01)	< 0.001	1.73 (1.40-2.15)	< 0.001
Within stage I					1.43 (0.87-2.37)	< 0.001	1.62 (1.02-2.56)	0.042
Within stage II					1.64 (1.23-2.20)	0.160	1.70 (1.28-2.27)	< 0.001
Within stage III					1.98 (1.61-2.43)	0.001	2.14 (1.74-2.63)	< 0.001
Within stage IV					1.46 (0.56-3.83)	< 0.001	1.93 (0.63-5.91)	0.251
All-cause mortality
Entire cohort	2.70 (2.36-3.10)	< 0.001	1.95 (1.68-2.26)	< 0.001	1.99 (1.59-2.48)	< 0.001	2.07 (1.70-2.51)	< 0.001
Within stage I					2.34 (1.49-3.67)	< 0.001	2.47 (1.64-3.74)	< 0.001
Within stage II					1.81 (1.22-2.69)	0.003	1.80 (1.31-2.49)	< 0.001
Within stage III					1.78 (1.44-2.20)	< 0.001	1.89 (1.52-2.35)	< 0.001
Within stage IV					0.71 (0.27-1.86)	0.490	1.31 (0.58-2.96)	0.510
Liver-cause mortality
Entire cohort	3.16 (2.70-3.70)	< 0.001	2.16 (1.82-2.56)	< 0.001	2.09 (1.61-2.72)	< 0.001	2.15 (1.73-2.67)	< 0.001
Within stage I					2.36 (1.31-4.26)	0.004	2.15 (1.43-3.24)	< 0.001
Within stage II					1.95 (1.21-3.15)	0.006	1.88 (1.29-2.72)	0.001
Within stage III					2.00 (1.58-2.55)	< 0.001	2.12 (1.67-2.69)	< 0.001
Within stage IV					0.67 (0.24-1.92)	0.460	0.96 (0.37-2.48)	0.932

CI: Confidence interval; HCC: Hepatocellular carcinoma; IPTW: Inverse-probability of treatment weighting.