Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study

Table 2 Demographic data (continuous) of hepatocellular carcinoma patients undergoing liver resection, n = 3985

Variables		Total	S-HCC, < 10 cm	L-HCC, > 10 cm	P value
		Mean ± SD	Mean ± SD	Mean ± SD
Tumor size	cm	4.41 ± 3.98	3.36 ± 2.14	13.14 ± 4.95	< 0.001
Age	yr	58.7 ± 12.4	59.1 ± 12.1	55.7 ± 14.3	< 0.001
Alpha-fetoprotein	ng/mL	6156.3 ± 60012	2400.7 ± 19087	40531.8 ± 178925	< 0.001
Albumin	g/dL	3.8 ± 0.6	3.8 ± 0.6	3.5 ± 0.7	< 0.001
Alkaline phosphatase	U/L	97.9 ± 104.4	90.1 ± 75.6	161.1 ± 221.4	< 0.001
AST	U/L	81.3 ± 158.1	76.4 ± 140.0	121.8 ± 261.2	< 0.001
ALT	U/L	85.1 ± 144.8	84.2 ± 133.5	92.2 ± 217.0	0.290
Bilirubin-direct	mg/dL	0.4 ± 0.8	0.4 ± 0.8	0.4 ± 0.6	0.400
Bilirubin-total	mg/dL	1.1 ± 1.3	1.1 ± 1.4	1.1 ± 1.0	0.680
ICG-15	%	9.7 ± 7.9	9.9 ± 8.1	8.0 ± 5.8	< 0.001
PT	seconds	11.8 ± 2.1	11.7 ± 2.0	12.0 ± 2.6	0.019

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; HCC: Hepatocellular carcinoma; ICG-15: Indocyanine green retention test at 15 minutes; L-HCC: Hepatocellular carcinoma ≥ 10 cm; PT: Prothrombin time; SD: Standard deviation; S-HCC: Hepatocellular carcinoma < 10 cm.