Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study

doi:10.4240/wjgs.v13.i5.476

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224

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May 27, 2021 (publication date) through Jul 29, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. May 27, 2021; 13(5): 476-492
Published online May 27, 2021. doi: 10.4240/wjgs.v13.i5.476

Table 1 Demographic data (categorical) of hepatocellular carcinoma patients undergoing liver resection, n (%), n = 3985

Variables		Total	S-HCC, < 10 cm	L-HCC, ≥ 10 cm	P value
Number¹		3985 (100)	3559 (89)	426 (11)
Gender	Male	3061 (77)	2716 (76)	345 (81)	0.031
Age	≤ 20	9 (< 1)	4 (< 1)	5 (1)	< 0.001
	21-40	292 (7)	240 (7)	52 (12)
	41-60	1668 (42)	1478 (42)	190 (45)
	≥ 61	2016 (51)	1837 (52)	179 (42)
Diabetes	Yes	831 (21)	764 (21)	67 (16)	0.006
Hypertension	Yes	1172 (29)	1053 (30)	119 (28)	0.480
HBV surface antigen	Positive	2074 (52)	1849 (52)	225 (53)	0.740
Anti-HCV antibody	Positive	1135 (28)	1091 (31)	44 (10)	< 0.001
Non-HBV non-HCV	Yes	986 (25)	815 (23)	171 (40)	< 0.001
Cigarette smoking	Yes	380 (10)	330 (9)	50 (12)	0.100
Alcohol consumption	Yes	322 (8)	277 (8)	45 (11)	0.047
Betel nut	Yes	109 (3)	93 (3)	16 (4)	0.170
AJCC 6^th (2002-2009)		1771	1577	194
	Stage I	1035 (58)	973 (62)	62 (32)	< 0.001
	Stage II	347 (20)	307 (19)	40 (21)
	Stage III	364 (21)	279 (18)	85 (44)
	Stage IV	25 (1)	18 (1)	7 (4)
AJCC 7^th (2010-2015)		2214	1982	232
	Stage I	1064 (48)	1031(52)	33 (14)	< 0.001
	Stage II	783 (35)	717 (36)	66 (28)
	Stage III	341 (15)	220 (11)	121 (52)
	Stage IV	26 (1)	14 (1)	12 (5)

¹Number excluded surgical mortality (30-d mortality).

AJCC: American Joint Committee on Cancer; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus; L-HCC: Hepatocellular carcinoma ≥ 10 cm; S-HCC: Hepatocellular carcinoma < 10 cm.

Citation: Lee CW, Yu MC, Wang CC, Lee WC, Tsai HI, Kuan FC, Chen CW, Hsieh YC, Chen HY. Liver resection for hepatocellular carcinoma larger than 10 cm: A multi-institution long-term observational study. World J Gastrointest Surg 2021; 13(5): 476-492
URL: https://www.wjgnet.com/1948-9366/full/v13/i5/476.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i5.476