Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection

Table 7 Univariate and multivariate analysis for overall survival in pancreatic ductal adenocarcinoma patients undergoing radical R0 resection according to the combination of preoperative fibrinogen and D-dimer

Characteristics	HR (95%CI)	Wald	P value	MOS (mo)
Univariate analysis
Preoperative combined grouping	2.500 (1.806-3.462)	—	0.000
Any-high group				15.43
Low-low group				31.17
Multivariate analysis
Age (year)	1.308 (0.985-1.736)	3.447	0.063
> 60				16.73
≤ 60				18.67
Degree of differentiation		36.927	0.000
Poorly/well	5.267 (2.871-9.663)	28.794	0.000	8.07 vs 51.77
Moderately/well	1.631 (1.011-2.633)	4.012	0.045	18.40 vs 51.77
Capsular invasion	0.691 (0.471-1.013)	3.579	0.059
Absent				24.00
Present				16.73
Lymph node metastasis	0.663 (0.497-0.883)	7.882	0.005
Absent				19.90
Present				15.03
Preoperative CA19-9 level (U/mL)	1.699 (1.258-2.293)	11.960	0.001
> 336.4				12.23
≤ 336.4				19.90
Adjuvant therapy	1.582 (1.202-2.081)	10.731	0.001
Absent				14.17
Present				20.37
Preoperative combined grouping	2.397 (1.723-3.335)	26.908	0.000
Any-high group				15.43
Low-low group				31.17

The any-high group for preoperative fibrinogen concentration > 3.31 g/L and/or preoperative D-dimer concentration > 0.53 mg/L group; the low-low group for preoperative fibrinogen concentration ≤ 3.31 g/L and preoperative D-dimer concentration ≤ 0.53 mg/L group. MOS: Median overall survival.