Model for liver hardness using two-dimensional shear wave elastography, durometer, and preoperative biomarkers

Table 2 Correlation between preoperative clinical parameters and durometer measurements

Parameters	Correlation coefficient R with subjective scale
	Pearson r (95%CI)	P value	Spearman r (95%CI)	P value
Age in yr	0.150 (-0.144-0.377)	0.201	0.024 (-0.211-0.273)	0.839
INR	0.097 (-0.125-0.306)	0.416	0.138 (0.127-0.350)	0.249
PT in s	0.197 (-0.122-0.318)	0.093	0.139 (-0.172-0.353)	0.239
TT in s	0.232 (-0.086-0.376)	0.046	0.219 (-0.055-0.406)	0.061
Platelet as 109/L	–0.244 (-0.405-0.043)	0.039	-0.313 (-0.475-0.071)	0.008
Albumin in g/L	–0.382 (-0.522-0.073)	0.005	-0.359 (-0.518-0.037)	0.002
ALT in U/L	0.144 (-0.003-0.327)	0.227	0.299 (-0.088-0.441)	0.011
AST in U/L	0.192 (0.034-0.417)	0.106	0.340 (-0.071-0.469)	0.004
TB in µmol/L	0.015 (-0.165-0.151)	0.901	-0.049 (-0.278-0.241)	0.683
Cholinesterase in U/L	–0.298 (-0.479-0.104)	0.026	–0.263 (-0.476-0.000)	0.05
GGT in U/L	0.053 (-0.121-0.149)	0.662	0.043 (-0.257-0.244)	0.719
Creatinine in μmol/L	0.152 (-0.067-0.280)	0.205	0.298 (-0.144-0.342)	0.012
HBV–DNA in U/mL	-0.043 (-0.012-0.185)	0.749	0.110 (-0.070-0.538)	0.415
HBsAg in IU/mL	0.269 (-0.345-0.390)	0.023	0.358 (0.018-0.612)	0.002
HA in μg/L	0.547 (0.176-0.661)	< 0.001	0.578 (0.246-0.723)	< 0.001
Preoperative FIB–4	0.128 (-0.085-0.474)	0.284	0.378 (0.084-0.633)	0.001
Stiffness in kPa	0.704 (0.607-0.789)	< 0.001	0.769 (0.639-0.850)	< 0.001
Palpation scale	0.729 (0.524-0.861)	< 0.001	0.729 (0.509-0.859)	< 0.001
Hospital stay in d	0.261 (0.059-0.420)	0.042	0.352 (0.123-0.561)	0.005

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CI: Confidence interval; FIB-4: Fibrosis-4; GGT: γ-Glutamine transpeptidase; HA: Hyaluronic acid; HBsAg: Hepatitis B surface antigen; INR: International normalized ratio; PT: Prothrombin time; TB: Total bilirubin; TT: Thrombin time.