Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia

doi:10.4240/wjgs.v13.i12.1708

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Dec 27, 2021 (publication date) through Nov 7, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Dec 27, 2021; 13(12): 1708-1720
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1708

Table 3 Spearman’s rank correlation for immunohistocehmical expression of ghrelin and ghrelin receptor in adenoma and adjacent tissue with the grade of adenoma dysplasia

	ISI for ghrelin in adenoma	ISI for ghrelin in adjacent tissue	ISI for ghrelin receptor in adenoma	ISI for ghrelin receptor in adjacent tissue
Low grade dysplasia
ISI for ghrelin in adenoma
Rho	1.000	0.173	-0.108	-0.096
P value		0.235	0.459	0.511
n	49	49	49	49
ISI for ghrelin in adjacent tissue
Rho	0.173	1.000	0.159	0.367
P value	0.235		0.276	0.009^a
n	49	49	49	49
ISI for ghrelin receptor in adenoma
Rho	-0.108	0.159	1.000	0.576
P value	0.459	0.276		< 0.001^b
n	49	49	49	49
ISI for ghrelin receptor in adjacent tissue
Rho	-0.096	0.367	0.576	1.000
P value	0.511	0.009	0.000
n	49	49	49	49
High grade dysplasia
ISI for ghrelin in adenoma
Rho	1.000	0.347	0.519	0.077
P value		0.023^d	< 0.001^c	0.622
n	43	43	43	43
ISI for ghrelin in adjacent tissue
Rho	0.347	1.000	0.230	0.409
P value	0.023^d		0.138	0.007^e
n	43	43	43	43
ISI for ghrelin receptor in adenoma
Rho	0.519	0.230	1.000	0.467
P value	< 0.001^c	0.138		0.002^f
n	43	43	43	43
ISI for ghrelin receptor in adjacent tissue
Rho	0.077	0.409	0.467	1.000
P value	0.622	0.007^e	0.002^f
n	43	43	43	43

^aP = 0.009 positive correlation between expression of ghrelin and ghrelin receptor in adjacent tissue for low grade dysplasia adenoma.

^bP < 0.001 positive correlation between expression of ghrelin receptor in adenoma and adjacent tissue for low grade dysplasia adenoma.

^cP < 0.001 positive correlation between expression of ghrelin and ghrelin receptor in adenoma for high grade dysplasia adenoma.

^dP = 0.023 positive correlation between expression of ghrelin in adenoma and adjacent tissue for high grade dysplasia adenoma.

^eP = 0.007 positive correlation between expression of ghrelin and ghrelin receptor in adjacent tissue for high grade dysplasia adenoma.

^fP = 0.002 positive correlation between expression of ghrelin and ghrelin receptor in adjacent tissue for low grade dysplasia adenoma.

ISI: Immunohistochemical staining index; Rho: Spearman correlation coefficient.

Citation: Stojsavljevic-Shapeski S, Virovic-Jukic L, Tomas D, Duvnjak M, Tomasic V, Hrabar D, Kralj D, Budimir I, Barsic N, Ljubicic N. Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia. World J Gastrointest Surg 2021; 13(12): 1708-1720
URL: https://www.wjgnet.com/1948-9366/full/v13/i12/1708.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i12.1708