Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia

doi:10.4240/wjgs.v13.i12.1708

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 13, Issue 12

This Article

Academic Content and Language Evaluation of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3570)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-4) series, Tables (1-3) series.

Item

Count

PDF

213

WORD

110

HTML

1494

Figures (1-4)

203

Tables (1-3)

169

Sum=2189

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

429

Download

952

Sum=1381

Dec 27, 2021 (publication date) through Dec 27, 2024

Times Cited of This Article

Times Cited (4)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Surgery

ISSN

1948-9366

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastrointest Surg. Dec 27, 2021; 13(12): 1708-1720
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1708

Table 3 Spearman’s rank correlation for immunohistocehmical expression of ghrelin and ghrelin receptor in adenoma and adjacent tissue with the grade of adenoma dysplasia

	ISI for ghrelin in adenoma	ISI for ghrelin in adjacent tissue	ISI for ghrelin receptor in adenoma	ISI for ghrelin receptor in adjacent tissue
Low grade dysplasia
ISI for ghrelin in adenoma
Rho	1.000	0.173	-0.108	-0.096
P value		0.235	0.459	0.511
n	49	49	49	49
ISI for ghrelin in adjacent tissue
Rho	0.173	1.000	0.159	0.367
P value	0.235		0.276	0.009^a
n	49	49	49	49
ISI for ghrelin receptor in adenoma
Rho	-0.108	0.159	1.000	0.576
P value	0.459	0.276		< 0.001^b
n	49	49	49	49
ISI for ghrelin receptor in adjacent tissue
Rho	-0.096	0.367	0.576	1.000
P value	0.511	0.009	0.000
n	49	49	49	49
High grade dysplasia
ISI for ghrelin in adenoma
Rho	1.000	0.347	0.519	0.077
P value		0.023^d	< 0.001^c	0.622
n	43	43	43	43
ISI for ghrelin in adjacent tissue
Rho	0.347	1.000	0.230	0.409
P value	0.023^d		0.138	0.007^e
n	43	43	43	43
ISI for ghrelin receptor in adenoma
Rho	0.519	0.230	1.000	0.467
P value	< 0.001^c	0.138		0.002^f
n	43	43	43	43
ISI for ghrelin receptor in adjacent tissue
Rho	0.077	0.409	0.467	1.000
P value	0.622	0.007^e	0.002^f
n	43	43	43	43

^aP = 0.009 positive correlation between expression of ghrelin and ghrelin receptor in adjacent tissue for low grade dysplasia adenoma.

^bP < 0.001 positive correlation between expression of ghrelin receptor in adenoma and adjacent tissue for low grade dysplasia adenoma.

^cP < 0.001 positive correlation between expression of ghrelin and ghrelin receptor in adenoma for high grade dysplasia adenoma.

^dP = 0.023 positive correlation between expression of ghrelin in adenoma and adjacent tissue for high grade dysplasia adenoma.

^eP = 0.007 positive correlation between expression of ghrelin and ghrelin receptor in adjacent tissue for high grade dysplasia adenoma.

^fP = 0.002 positive correlation between expression of ghrelin and ghrelin receptor in adjacent tissue for low grade dysplasia adenoma.

ISI: Immunohistochemical staining index; Rho: Spearman correlation coefficient.

Citation: Stojsavljevic-Shapeski S, Virovic-Jukic L, Tomas D, Duvnjak M, Tomasic V, Hrabar D, Kralj D, Budimir I, Barsic N, Ljubicic N. Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia. World J Gastrointest Surg 2021; 13(12): 1708-1720
URL: https://www.wjgnet.com/1948-9366/full/v13/i12/1708.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i12.1708