Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia

Table 2 Correlation of immunohistochemical expression of ghrelin and ghrelin receptor based on two groups of immunohistochemical staining index value in adenoma and adjacent tissue to the stage of adenoma dysplasia

	Dysplasia grade				P value
	Low dysplasia		High dysplasia
	n	%	n	%
ISI for ghrelin in adenoma					0.048a
ISI < 9	48	98.0	37	86.0
ISI 9-strong reaction	1	2.0	6	14.0
ISI for ghrelin in adjacent tissue					1.000
ISI 0 < 6	42	85.7	37	86.0
ISI 6-moderate reaction	7	14.3	6	14.0
ISI for ghrelin receptor in adenoma					0.114
ISI < 9	43	87.8	32	74.4
ISI 9-strong reaction	6	12.2	11	25.6
ISI for ghrelin receptor in adjacent tissue					0.664
ISI < 9	30	61.2	29	67.4
ISI 9-strong reaction	19	38.8	14	32.6

^aP = 0.048 for strong ghrelin expression in adenoma with high vs low grade dysplasia.

ISI: Immunohistochemical staining index.