Advances in liver transplantation for unresectable colon cancer liver metastasis

Table 2 Inclusion criteria in some prospective studies on liver transplantation for colorectal cancer liver metastasis

Study	SECA I	SECA II	LIVERTWOHEAL	TRANSMET	Toronto NCT02864485
Inclusion criteria	Primary tumor R0 resected; ECOG 0-1; More than 6 wk chemotherapy; No extrahepatic metastasis or recurrence confirmed by PET/CT, bone scan	Addition standard: No signs of extra hepatic metastatic disease (except resectable lung metastasis) or local recurrence according to coloscopy, CT or MRI within 12 mo; Chemotherapy response > 10%, If not, TACE or Y-90 response > 20%; More than 12 mo from diagnosis or adjuvant therapy	Unresectable CRLM without extrahepatic tumor burden, except resectable pulmonary metastases; Disease regresses or keeps stable after more than 8 wk chemotherapy	ECOG 0-1; BRAF wild type; Primary tumor R0 resected; No primary recurrence within 12 mo confirmed by coloscopy. Disease stable or regress more than 3 mo with chemotherapy; CEA < 80 ng/mL or decrease ≥ 50%; No extrahepatic metastasis confirmed by CT or PET-CT	ECOG 0-1; Primary tumor stage is ≤ T4a; More than 6 mo since liver resection; No major vascular invasion; More than 3 mo chemotherapy; Disease regression or stable more than 3 mo; Stable CEA value or decease at all time prior to LT
Outcome	OS	OS 10 yr	OS 3 yr	OS 5 yr	OS 5 yr; PFS 5 yr

TACE: Transcatheter arterial chemoembolization; Y-90: Yttrium; PET/CT: Positron emission tomography/computed tomography; MRI: Magnetic resonance imaging.