Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in inflammatory response to liver injury in Budd-Chiari syndrome

doi:10.4240/wjgs.v13.i11.1448

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Nov 27, 2021; 13(11): 1448-1462
Published online Nov 27, 2021. doi: 10.4240/wjgs.v13.i11.1448

Table 3 Relative protein expression levels of TLR4/NF-κB-mediated inflammation-related indicators

	TLR4	NF-κBp65	IL-2	TNF-α	IFN-γ
Control group	0.555 ± 0.066	0.317 ± 0.022	0.232 ± 0.029	0.368 ± 0.032	0.369 ± 0.023
Sham-operated group
1W	0.561 ± 0.059	0.327 ± 0.019	0.229 ± 0.028	0.366 ± 0.026	0.379 ± 0.029
3W	0.560 ± 0.068	0.313 ± 0.023	0.242 ± 0.029	0.357 ± 0.022	0.359 ± 0.026
6W	0.561 ± 0.071	0.310 ± 0.030	0.236 ± 0.027	0.369 ± 0.034	0.362 ± 0.020
12W	0.564 ± 0.070	0.309 ± 0.025	0.234 ± 0.027	0.371 ± 0.028	0.377 ± 0.028
Model group
1W	0.729 ± 0.067^a^,^b	0.678 ± 0.058^a^,^b	0.449 ± 0.057^a^,^b	0.684 ± 0.024^a^,^b	0.700 ± 0.082^a^,^b
3W	1.507 ± 0.086^a^,^b	1.416 ± 0.087^a^,^b	1.047 ± 0.058^a^,^b	1.188± 0.051^a^,^b	1.261 ± 0.073^a^,^b
6W	1.162 ± 0.070^a^,^b	1.192 ± 0.079^a^,^b	0.848 ± 0.056^a^,^b	1.050 ± 0.043^a^,^b	1.069 ± 0.090^a^,^b
12W	1.001 ± 0.072^a^,^b	0.880 ± 0.090^a^,^b	0.610 ± 0.059^a^,^b	0.835 ± 0.065^a^,^b	0.845 ± 0.063^a^,^b
Statistics	291.836	711.802	608.214	897.062	488.525
P value	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001

^aP < 0.05, comparisons between subgroups, the differences are statistically significant.

^bP < 0.05, comparisons between model subgroups, the differences are statistically significant.

TLR4: Toll-like receptor 4; NF-κB: Nuclear factor-κB; TNF-α: Tumor necrosis factor-α; IL-2: Interleukin-2; IFN-γ: Interferon-γ.

Citation: Li J, Chen XM, Zhou CZ, Fang WW, Lv WF, Cheng DL. Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in inflammatory response to liver injury in Budd-Chiari syndrome. World J Gastrointest Surg 2021; 13(11): 1448-1462
URL: https://www.wjgnet.com/1948-9366/full/v13/i11/1448.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i11.1448