Novel roles of lipopolysaccharide and TLR4/NF-κB signaling pathway in inflammatory response to liver injury in Budd-Chiari syndrome

Table 2 mRNA expression levels of TLR4/NF-κB-mediated inflammation-related indicators

	TLR4	NF-κBp65	IL-2	TNF-α	IFN-γ
Control group	1.004 ± 0.139	1.003 ± 0.074	1.001 ± 0.121	1.001 ± 0.126	1.005 ± 0.101
Sham-operated group
1W	1.101 ± 0.127	1.101 ± 0.127	1.108 ± 0.206	1.068 ± 0.222	1.102 ± 0.121
3W	1.013 ± 0.109	1.013 ± 0.109	1.061 ± 0.168	1.042 ± 0.181	1.082 ± 0.111
6W	1.045 ± 0.118	1.045 ± 0.118	1.006 ± 0.141	1.047 ± 0.164	1.004 ± 0.084
12W	1.059 ± 0.115	1.059 ± 0.115	1.025 ± 0.097	1.017 ± 0.157	1.019 ± 0.118
Model group
1W	1.773 ± 0.165a,b	1.773 ± 0.165a,b	1.935 ± 0.217a,b	1.991 ± 0.181a,b	2.170 ± 0.195a,b
3W	6.789 ± 0.692a,b	6.789 ± 0.692a,b	6.144 ± 0.681a,b	12.931 ± 1.424a,b	9.172 ± 0.902a,b
6W	4.671 ± 0.593a,b	4.671 ± 0.593a,b	4.372 ± 0.268a,b	7.629 ± 0.999a,b	5.131 ± 0.441a,b
12W	1.003 ± 0.074a,b	3.575 ± 0.334a,b	3.011 ± 0.326a,b	3.991 ± 0.391a,b	2.855 ± 0.732a,b
Statistics	333.288	464.025	426.396	555.318	509.268
P value	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001

^aP < 0.05, comparisons between subgroups, the differences are statistically significant.

^bP < 0.05, comparisons between model subgroups, the differences are statistically significant.

TLR4: Toll-like receptor 4; NF-κB: Nuclear factor-κB; TNF-α: Tumor necrosis factor-α; IL-2: Interleukin-2; IFN-γ: Interferon-γ.