Patients with Clostridium difficile infection and prior appendectomy may be prone to worse outcomes

Table 6 Multivariate analysis for primary and secondary outcomes

	Mortality		Recurrence		Toxic megacolon		Need for colectomy
Variable	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI	P value
Age	1.02 (1.01-1.03)	< 0.001	1.00 (0.99-1.01)	0.626			0.99 (0.96-1.02)	0.547
Female gender	Ref		Ref		Ref		Ref
Male gender	1.32 (0.97-1.81)	0.079	0.91 (0.67-1.22)	0.518	0.86 (0.17-4.00)	0.846	1.36 (0.55-3.46)	0.501
Prior appendectomy = no	Ref		Ref		Ref		Ref
Prior appendectomy = yes	1.03 (0.64-1.59)	0.905	0.92 (0.58-1.42)	0.727	5.37 (1.03-25.09)	0.031	2.77 (0.95-7.17)	0.044
Prior antibiotics (no)	Ref		Ref		Ref		Ref
Prior antibiotics (yes)	1.04 (0.76-1.43)	0.788	1.07 (0.79-1.44)	0.668	0.13 (0.01-0.81)	0.065	1.58 (0.62-4.31)	0.348
Prior steroids (no)	Ref		Ref		Ref		Ref
Prior steroids (yes)	0.72 (0.37-1.30)	0.309	1.08 (0.63-1.77)	0.774	1.99 (0.10-12.38)	0.533	0.41 (0.02-2.07)	0.391
Prior PPI (no)	Ref		Ref		Ref		Ref
Prior PPI (yes)	0.89 (0.62-1.27)	0.530	1.05 (0.74-1.46)	0.790	1.08 (0.15-5.38)	0.933	1.83 (0.71-4.60)	0.196
Prior chemotherapy (no)	Ref		Ref		Ref		Ref
Prior chemotherapy (yes)	0.92 (0.34-2.07)	0.851	0.76 (0.26-1.79)	0.570	-		4.26 (0.65-16.24)	0.063

Multivariate analysis for mortality and recurrence was performed using binomial logistic regression. Chemotherapy was not included in the analysis of toxic megacolon due to convergence issues. OR: Odds ratio; CI: Confidence interval; PPI: Proton pump inhibitors.