Patients with Clostridium difficile infection and prior appendectomy may be prone to worse outcomes

doi:10.4240/wjgs.v13.i11.1436

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Nov 27, 2021; 13(11): 1436-1447
Published online Nov 27, 2021. doi: 10.4240/wjgs.v13.i11.1436

Table 3 Comparison of the Clostridium difficile infection outcomes based on the prior appendectomy status and the inverse probability of treatment weights analysis

Outcome	Total	No prior appendectomy	Prior appendectomy	OR (95%CI)	P value
n	1580	1382	198
n IP-weighted		1572	1354
Mortality
n (%)	220 (13.9)	193 (14.2)	27 (13.7)	0.97 (0.61-1.47)	0.877
n IP-weighted (%)		218 (14)	207 (15.5)	1.12 (0.65-1.92)	0.685
Recurrence
n (%)	228 (14.4)	199 (14.4)	29 (14.6)	1.02 (0.66-1.54)	0.915
n IP-weighted (%)		228 (14.5)	204 (15.1)	1.05 (0.66-1.67)	0.847
Toxic megacolon
n (%)	7 (0.4)	4 (0.34)	3 (1.57)	4.75 (0.87-22.9)	0.069
n IP-weighted (%)		5 (0.3)	19 (1.5)	4.32 (0.91-20.57)	0.066
Colectomy
n (%)	22 (1.4)	16 (1.19)	6 (3.06)	2.65 (0.93-6.59)	0.067
n IP-weighted (%)		18 (1.2)	24 (1.8)	1.53 (0.55-4.27)	0.413
Severity (IDSA)
Before IPTW				1.32 (1.01-1.75)	0.043
Mild, n (%)	710 (44.9)	634 (45.9)	76 (38.4)
Severe, n (%)	566 (35.8)	489 (35.4)	77 (38.9)
Fulminant, n (%)	304 (19.2)	259 (18.7)	45 (22.7)
After IPTW				1.59 (1.15-2.18)	0.005
Mild, n (%)		724 (46.1)	472 (34.8)
Severe, n (%)		557 (35.4)	526 (38.8)
Fulminant, n (%)		291 (18.5)	356 (26.3)
LOS among survivors
Median (IQR)		9 (5.00; 18.0)	10 (6.50; 20.0)	1.1 (0.94-1.28)	0.233
Median (IQR)-IPTW		10 (5.00; 20.0)	12 (7.00; 23.00)	0.9 (0.74-1.1)	0.318

Data were summarized using counts and percentages before inverse probability of treatment weights (IPTW) and weighed counts and percentages after IPTW. Statistical analysis was performed using logistic regression for categorical variables and Poisson regression for length of stay (LOS). Analysis for LOS included only patients who were discharged. Ordinal logistic regression was used to assess the association between history of appendectomy and Infectious Diseases Society of America severity. CI: Confidence interval; OR: Odds ratio; IQR: Interquartile range; IPTW: Inverse probability of treatment weights; LOS: Length of stay; IDSA: Infectious Diseases Society of America.

Citation: Shaikh DH, Patel H, Munshi R, Sun H, Mehershahi S, Baiomi A, Alemam A, Pirzada U, Nawaz I, Naher K, Hanumanthu S, Nayudu S. Patients with Clostridium difficile infection and prior appendectomy may be prone to worse outcomes. World J Gastrointest Surg 2021; 13(11): 1436-1447
URL: https://www.wjgnet.com/1948-9366/full/v13/i11/1436.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i11.1436