Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

Table 9 Treatment-related potential prognostic factors for liver and lung recurrence

	Recurrence, n = 58
	Liver				Lung
	No, n = 33 (55.0%)	Yes, n = 25 (41.7%)	HR (95%CI)	P value	No, n = 42 (70.0%)	Yes, n = 16 (26.7%)	HR (95%CI)	P value
Neoadjuvant therapy, n (%)				0.952				0.010
No	13 (46.4)	15 (53.6)	Reference		21 (75)	7 (25)	Reference
Yes	2 (100)	0 (0)	0.91 (0.04-18.42)		0 (0)	2 (100)	13.21 (1.86-93.92)
Missing	18	10			21	7
Surgery, n (%)
Right emicolectomy	10 (83.3)	2 (16.7)	Reference		10 (83.3)	2 (16.7)	Reference
Extended right emicolectomy	1 (33.3)	2 (66.7)	2.02 (0.31-13.21)	0.461	2 (66.7)	1 (33.3)	0.81 (0.09-7.66)	0.857
Intermediate colectomy	0 (0)	4 (100)	7.05 (1.34-36.94)	0.021	4 (100)	0 (0)	0.75 (0.03-21.49)	0.864
AR/Hartmann’s procedure	11 (44)	14 (56)	2.44 (0.59-10.18)	0.220	19 (76)	6 (24)	1.07 (0.21-5.39)	0.936
Low anterior resection/Miles	9 (90)	1 (10)	0.54 (0.06-4.67)	0.579	3 (30)	7 (70)	2.20 (0.45-10.78)	0.332
Total/Sub-total colectomy	2 (66.7)	1 (33.3)	2.37 (0.27-20.60)	0.433	3 (100)	0 (0)	0.84 (0.03-24.19)	0.920
Segmental resection	0 (0)	1 (100)	110 (5.3-2304.7)	0.002	1 (100)	0 (0)	-	-
Associated procedure, n (%)
No	4 (33.3)	8 (66.7)	Reference		10 (83.3)	2 (16.7)	Reference
Minor	9 (69.2)	4 (30.8)	0.37 (0.11-1.23)	0.106	10 (76.9)	3 (23.1)	0.92 (0.16-5.43)	0.928
Major	2 (28.6)	5 (71.4)	1.65 (0.53-5.47)	0.377	4 (57.1)	3 (42.9)	3.37 (0.55-20.65)	0.188
Missing	18	8			18	8
Operative technique, n (%)				0.253				0.658
Open	19 (51.4)	18 (48.6)	Reference		27 (73)	10 (27)	Reference
Laparoscopy	14 (66.7)	7 (33.3)	0.60 (0.25-1.44)		15 (71.4)	6 (28.6)	0.79 (0.28-2.24)
Duration of surgery, min, mean ± SD	250 ± 90	227 ± 75	1.00 (0.99-1.00)	0.579	231 ± 83	264 ± 86	1.00 (1.00-1.01)	0.221
Hospital stay, d, mean ± SD	10.0 ± 3.9	9.5 ± 2.1	0.97 (0.84-1.11)	0.637	9.8 ± 2.8	9.9 ± 4.3	1.00 (0.86-1.17)	0.980
Postoperative blood transfusion, n (%)				0.067				0.992
No	20 (50)	20 (50)	Reference		30 (75)	10 (25)	Reference
Yes	13 (76.5)	4 (23.5)	0.37 (0.12-1.07)		11 (64.7)	6 (35.3)	0.99 (0.36-2.75)
Missing	-	1			1	-
Reoperation due to complications, n (%)				0.723				0.705
No	12 (57.1)	9 (42.9)	Reference		18 (85.7)	3 (14.3)	Reference
Yes	2 (100)	0 (0)	0.58 (0.03-12.07)		1 (50)	1 (50)	1.53 (0.17-13.57)
Missing	19	16			23	12
Adjuvant therapy, n (%)				0.055				0.703
No	16 (72.7)	6 (27.2)	Reference		15 (68.2)	7 (31.8)	Reference
Yes	14 (45.2)	17 (54.8)	2.52 (0.98-6.48)		23 (74.2)	8 (25.8)	1.23 (0.42-3.62)
Missing	3	2			4	1
Start of adj CHT, n (%)				0.913				0.344
< 6 wk from surgery	6 (46.2)	7 (53.8)	Reference		8 (61.5)	5 (38.6)	Reference
≥ 6 wk from surgery	4 (44.4)	5 (55.6)	1.07 (0.33-3.43)		8 (88.9)	1 (11.1)	0.35 (0.04-1.04)
Missing	23	13			26	10

HR: Hazard ratio; OR: Odds ratio; CI: Confidential intervals; Adj CHT: Adjuvant chemotherapy.