Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

Table 8 Demographic and patient-related preoperative potential prognostic factors for liver and lung recurrence

	Recurrence, n = 58
	Liver				Lung
	No, n = 33 (55.0%)	Yes, n = 25 (41.7%)	HR (95%CI)	P value	No, n = 42 (70.0%)	Yes, n = 16 (26.7%)	HR (95%CI)	P value
Age, yr, mean ± SD	67.4 ± 12.3	68.0 ± 12.3	1.00 (0.97-1.03)	0.945	67.3 ± 12.7	68.7 ± 11.0	1.00 (0.96-1.04)	0.837
Gender, n (%)				0.702				0.185
Male	16 (55.2)	13 (44.8)	Reference		19 (65.5)	10 (34.5)	Reference
Female	17 (58.6)	12 (41.4)	0.86 (0.39-1.88)		23 (79.3)	6 (20.7)	0.50 (0.18-1.39)
Preop Hb, g/dL, mean ± SD	11.28	11.93	1.16 (0.88-1.53)	0.296	11.4 ± 2.3	12.0 ± 2.5	1.14 (0.81-1.61)	0.446
Preop glycemia, g/dL, mean ± SD	1.08 ± 0.36	1.08 ± 0.31	1.72 (0.14-10.00)	0.884	1.06 ± 0.33	1.14 ± 0.35	1.47 (0.12-18.20)	0.764
Preop total proteins, g/dL, mean ± SD	6.7 ± 0.7	7.1 ± 0.8	1.33 (0.56-3.17)	0.514	6.9 ± 0.9	6.9 ± 0.5	0.87 (0.19-3.93)	0.861
Preop CEA, n (%)				0.868				0.891
< 5 ng/mL	6 (46.2)	7 (53.8)	Reference		10 (76.9)	3 (23.1)	Reference
≥ 5 ng/mL	4 (57.1)	3 (42.9)	0.89 (0.23-3.46)		5 (71.4)	2 (28.6)	1.14 (0.18-7.14)
Missing	23	15			27	11
BMI, mean ± SD	26.3 ± 4.9	27.8 ± 4.7	1.04 (0.94-1.15)	0.465	27.6 ± 4.8	25.7 ± 4.6	0.96 (0.83-1.13)	0.646
ASA, n (%)
1	3 (60)	2 (40)	Reference		4 (80)	1 (20)	Reference
2	8 (42.1)	11 (57.9)	0.64 (0.15-2.75)	0.544	14 (73.7)	5 (26.3)	0.46 (0.06-3.38)	0.447
3	13 (61.9)	8 (38.1)	0.34 (0.07-1.55)	0.163	15 (71.4)	6 (28.6)	0.31 (0.04-2.35)	0.258
4	3 (100)	0 (0.0)	0.30 (0.01-7.69)	0.471	2 (66.7)	1 (33.3)	2.09 (0.16-27.56)	0.573
Missing	6	4			7	3
Presentation with occlusion, n (%)				0.465				0.470
No	5 (62.5)	3 (37.5)	Reference		6 (75)	2 (25)	Reference
Yes	6 (46.2)	7 (53.8)	1.58 (0.46-5.44)		9 (69.2)	4 (30.8)	1.89 (0.34-10.61)
Missing	23	15			27	11
Tumour site, n (%)
Right colon	11 (68.7)	5 (31.3)	Reference		13 (81.3)	3 (18.7)	Reference
Left colon	11 (42.3)	15 (57.7)	2.48 (0.89-6.88)	0.081	20 (76.9)	6 (23.1)	1.73 (0.42-7.04)	0.445
Rectum	11 (68.7)	5 (31.3)	0.98 (0.28-3.41)	0.972	9 (56.3)	7 (43.7)	2.34 (0.59-9.32)	0.226

HR: Hazard ratio; OR: Odds ratio; CI: Confidential intervals; Preop: Preoperative value; Hb: Haemoglobin; CEA: Carcinoembryonic antigen; BMI: Body mass index; ASA: American Society of Anaesthesiologists Score.