Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

Table 6 Pathological-related potential prognostic factors for recurrence and evaluation of early versus late recurrence (univariate analysis)

	Recurrence, n = 234					Timing of recurrence, n = 60
	All	No	Yes	HR (95%CI)	P value	Early recurrence (< 3 yr)	Late recurrence (≥ 3 yr)	OR (95%CI)	P value
	n (%)	n = 174 (67.7%)	n = 60 (23.3%)			n = 51 (85.0%)	n = 9 (15.0%)
Major tumor diameter, mm, mean ± SD	43 ± 23	41.6 ± 23	46.8 ± 24.5	1.01 (0.99-1.02)	0.130	47.6 ± 23.5	42.8 ± 29.8	0.99 (0.96-1.02)	0.694
Pathological T stage1, n (%)
1	46 (19.7)	44 (95.7)	2 (4.3)	Reference		2 (100)	0 (0)	Reference
2	40 (17.2)	32 (80)	8 (20)	3.44 (0.91-12.99)	0.068	6 (75)	2 (25)	0.64 (0.04-10.57)	0.756
3	141 (60.5)	94 (66.7)	47 (33.3)	6.14 (1.91-19.77)	0.002	40 (85.1)	7 (14.9)	0.27 (0.02-3.20)	0.298
4	6 (2.6)	4 (66.7)	2 (33.3)	6.19 (1.03-37.96)	0.046	2 (100)	0 (0)	0.33 (0.00-24.94)	0.624
Missing	1	1				1
Pathological N stage1, n (%)
0	155 (66.5)	129 (83.2)	26 (16.8)	Reference		18 (69.2)	8 (30.8)	Reference
1	51 (21.9)	36 (70.6)	15 (29.4)	1.95 (1.03-3.69)	0.039	15 (100)	0 (0)	0.07 (0.00-1.44)	0.085
2	27 (11.6)	9 (33.3)	18 (66.7)	6.35 (3.50-11.64)	< 0.001	17 (94.4)	1 (5.6)	0.19 (0.03-1.25)	0.084
Missing	1	1				1
Pathological M stage1, n (%)					< 0.001				0.408
0	223 (95.6)	171 (76.7)	52 (23.3)	Reference		43 (82.7)	9 (17.3)	Reference
1	10 (4.3)	2 (20)	8 (80)	5.31 (2.50-11.30)		8 (100)	0 (0)	0.27 (0.01-6.02)
Missing	1	1				-
AJCC stage, n (%)
1	77 (32.9)	68 (88.3)	9 (11.7)	Reference		7 (77.8)	2 (22.2)	Reference
2	75 (32)	59 (78.7)	16 (21.3)	1.65 (0.74-3.67)	0.220	10 (62.5)	6 (37.5)	1.12 (0.20-6.17)	0.894
3	72 (30.8)	45 (62.5)	27 (37.5)	3.59 (1.73-7.42)	< 0.001	26 (96.3)	1 (3.7)	0.12 (0.01-1.03)	0.053
4	10 (4.3)	2 (20)	8 (80)	11.1 (4.35-28.52)	< 0.001	8 (100)	0 (0)	0.13 (0.00-3.43)	0.220
Retrieved LN, n (%)					0.535				0.741
< 12	65 (29.3)	53 (81.5)	12 (18.5)	Reference		10 (83.3)	2 (16.7)	Reference
≥ 12	157 (70.7)	112 (71.3)	45 (28.7)	0.84 (0.47-1.47)		38 (84.4)	7 (15.6)	0.78 (0.18-3.40)
Missing	12	12				3
LN ratio, mean ± SD	20 ± 16	16 ± 13	25 ± 19	25.8 (8.22-80.93)	< 0.001	25 ± 19	22	0.00 (0.00-2.20)	0.073
Colloid component, n (%)					0.168				0.607
No	63 (60)	49 (77.8)	14 (22.2)	Reference		12 (85.7)	2 (14.3)	Reference
Yes	42 (40)	27 (64.3)	15 (35.7)	1.68 (0.80-3.53)		13 (86.7)	2 (13.3)	0.55 (0.06-5.22)
Missing	129	129				31

¹According to the tumor node metastasis staging system.

AJCC: American Joint Committee on Cancer; LN: Lymph nodes; HR: Hazard ratio; OR: Odds ratio; CI: Confidential intervals.