Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

Table 2 Potential prognostic factor for disease-free survival and overall survival

	Disease free survival (DFS)			P value	Overall survival (OS)			P value
	3 yr (%)	5 yr (%)	10 y (%)		3 yr (%)	5 yr (%)	10 yr (%)
CEA				0.095				0.045
< 5 ng/mL	84.4	80.8	73.1		88.3	79.8	69.6
≥ 5 ng/mL	72.2	61.1	50.0		81.0	66.7	42.9
AJCC stage				< 0.0001				< 0.0001
1	86.9	82.9	70.6		91.1	83.5	70.4
2	87.7	76.2	57.9		92.9	82.1	54.3
3	59.3	57.9	50.6		72.0	61.0	48.5
4	20.0	-	-		63.6	45.5	18.2
Pathologic M stage1				< 0.0001				0.002
0	77.0	71.2	58.4		85.1	74.4	57.0
1	20.0	-	-		63.6	45.5	18.2
Retrieved LN				0.819				0.688
< 12	81.5	75.4	58.1		87.5	76.4	54.7
≥ 12	73.3	69.3	58.8		83.2	73.8	56.4
LN ratio				0.068				0.043
< 15	66.8	64.0	55.6		78.0	70.7	56.0
≥ 15	41.5	41.5	36.2		61.7	44.7	33.8
Timing of recurrence								0.028
Early (< 3 yr2)					54.9	33.3	11.8
Late (≥ 3 yr2)					100	77.8	22.2

¹According to the tumor node metastasis staging system.

²Recurrence from the first treatment.

CEA: Carcinoembryonic antigen; AJCC: American Joint Committee on Cancer; LN: Lymph node.