Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

Table 13 Pathological-related potential prognostic factors for local and peritoneal recurrence

	Recurrence, n = 58
	Peritoneal				Local
	No, n = 51 (87.9)	Yes, n = 7 (12.1)	HR (95%CI)	P value	No, n = 41 (70.7)	Yes, n = 17 (29.3)	HR (95%CI)	P value
Major tumor diameter, mm, mean ± SD	46.2 ± 22.4	64.0 ± 35.1	1.02 (0.99-1.05)	0.062	44.2 ± 19	55.8 ± 31.9	1.01 (0.99-1.03)	0.107
Pathological T stage1, n (%)
1	2 (100)	0 (0)	Reference		2 (100)	0 (0)	Reference
2	7 (87.5)	1 (12.5)	1.41 (0.03-62.92)	0.858	4 (50)	4 (50)	4.91 (0.19-124)	0.335
3	39 (86.7)	6 (13.3)	3.8 (0.05-270.74)	0.538	33 (73.3)	12 (23.7)	6.29 (0.22-177)	0.281
4	2 (100)	0 (0)	7.03 (0.04-1358)	0.468	1 (50)	1 (50)	21.47 (0.51-897)	0.107
Missing	1	-			1	-
Pathological N stage1, n (%)				0.196
0	25 (96.2)	1 (3.8)	Reference		17 (65.4)	9 (34.6)	Reference
1	11 (78.6)	3 (21.4)	14.5 (0.52-405.2)	0.115	8 (57.1)	6 (42.9)	2.41 (0.76-7.65)	0.135
2	14 (82.4)	3 (17.6)	15.4 (0.55-428)	0.107	15 (88.2)	2 (11.8)	0.88 (0.19-4.11)	0.874
Missing	1	-			1	-
Pathological M stage1, n (%)				0.546				0.032
0	44 (88)	6 (12)	Reference		37 (74)	13 (26)	Reference
1	7 (87.5)	1 (12.5)	1.84 (0.25-13.22)		4 (50)	4 (50)	3.57 (1.12-11.40)
AJCC Stage, n (%)
1	8 (88.9)	1 (11.1)	Reference		5 (55.6)	4 (44.4)	Reference
2	16 (100)	0 (0)	0.78 (0.01-73.61)	0.916	12 (75)	4 (25)	1.45 (0.28-7.51)	0.659
3	20 (80)	5 (20)	6.16 (0.21-178)	0.290	20 (80)	5 (20)	1.62 (0.31-8.37)	0.567
4	7 (87.5)	1 (12.5)	5.16 (0.12-215)	0.389	4 (50)	4 (50)	4.64 (0.84-25.69)	0.079
Retrieved LN, n (%)				1.000				0.477
< 12	10 (90.9)	1 (11.1)	Reference		8 (72.7)	3 (27.3)	Reference
≥ 12	38 (86.4)	6 (13.6)			31 (70.5)	13 (29.5)	1.56 (0.46-5.32)
Missing	3	-
LN Ratio, mean ± SD)	24 ± 17	27 ± 29	12.13 (0.84-174)	0.066	29 ± 20	15 ± 16	0.64 (0.04-11.17)	0.757
Colloid component, n (%)				0.106				0.396
No	13 (100)	0 (0)	Reference		9 (69.2)	4 (30.8)	Reference
Yes	10 (66.7)	5 (33.3)	13.77 (0.57-330)		9 (60)	6 (40)	1.77 (0.47-6.62)
Missing	28	2			23	7

¹According to the tumor node metastasis staging system.

HR: Hazard ratio; CI: Confidential intervals; AJCC: American Joint Committee on Cancer; LN: Lymph node.