Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

Table 12 Treatment-related potential prognostic factors for local and peritoneal recurrence

	Recurrence, n = 58
	Peritoneal				Local
	No, n = 51 (87.9%)	Yes, n = 7 (12.1%)	HR (95%CI)	P value	No, n = 41 (70.7)	Yes, n = 17 (29.3)	HR (95%CI)	P value
Neoadjuvant therapy, n (%)				0.569				0.475
No	23 (82.1)	5 (17.9)	Reference		23 (81.1)	5 (17.9)	Reference
Yes	2 (100)	0 (0)	2.71 (0.09-84.27)		2 (100)	0 (0)	3.88 (0.09-160.22)
Missing	26	2			16	12
Surgery, n (%)
Right emicolectomy	10 (83.3)	2 (16.7)	Reference		6 (50)	6 (50)	Reference
Extended right emicolectomy	3 (100)	0 (0)	0.23 (0.01-11.90)	0.468	2 (66.7)	1 (33.3)	0.20 (0.02-1.68)	0.140
Intermediate colectomy	4 (100)	0 (0)	1.20 (0.03-47.50)	0.923	4 (100)	0 (0)	0.35 (0.01-8.18)	0.511
AR/Hartmann’s procedure	23 (92)	2 (8)	0.36 (0.04-3.04)	0.350	17 (68)	8 (32)	0.41 (0.13-1.29)	0.127
Low Anterior resection/Miles	8 (80)	2 (20)	0.68 (0.07-6.27)	0.731	9 (90)	1 (10)	0.15 (0.02-1.07)	0.059
Total/Sub-total colectomy	2 (66.7)	1 (33.3)	2.99 (0.25-35.10)	0.383	2 (66.7)	1 (33.3)	0.98 (0.14-6.95)	0.981
Segmental resection	1 (100)	0 (0)	-	-	1 (100)	0 (0)	-	-
Associated procedure, n (%)
No	11 (91.7)	1 (8.3)	Reference		11 (91.7)	1 (8.3)	Reference
Minor	11 (84.6)	2 (15.4)	1.16 (0.10-14.11)	0.905	7 (53.8)	6 (46.2)	2.41 (0.33-17.37)	0.384
Major	7 (100)	0 (0)	0.61 (0.01-31.26)	0.808	5 (71.4)	2 (28.6)	3.26 (0.36-29.71)	0.295
Missing	22	4			18	8
Operative technique, n (%)				0.128				0.368
Open	35 (94.6)	2 (5.4)	Reference		25 (67.6)	12 (32.4)	Reference
Laparoscopy	16 (76.2)	5 (23.8)	3.64 (0.69-19.14)		16 (76.2)	5 (23.8)	0.61 (0.21-1.77)
Duration of surgery, min, mean ± SD	239 ± 85	249 ± 87	1.00 (0.99-1.01)	0.869	244 ± 81	232 ± 93	1.00 (0.99-1.01)	0.934
Hospital stay, d, mean ± SD	9.8 ± 3.2	10.0 ± 4.1	0.98 (0.76-1.27)	0.907	9.4 ± 3.3	10.7 ± 3.1	1.09 (0.96-1.23)	0.181
Postoperative blood transfusion, n (%)				0.272				0.518
No	37 (92.5)	3 (7.5)	Reference		30 (75)	10 (25)	Reference
Yes	13 (76.5)	4 (23.5)	2.32 (0.52-10.38)		10 (58.8)	7 (41.2)	1.39 (0.51-3.74)
Missing	1	-			1	-
Reoperation due to complications, n (%)				0.344				0.182
No	17 (81)	4 (19)	Reference		18 (75)	6 (25)	Reference
Yes	1 (50)	1 (50)	3.00 (0.31-29.24)		1 (50)	1 (50)	4.35 (0.50-37.59)
Missing	33	2			22	10
Adjuvant therapy, n (%)				0.481				0.852
No	20 (90.9)	2 (9.1)	Reference		14 (63.6)	8 (36.4)	Reference
Yes	28 (90.3)	3 (9.7)	2.26 (0.23-21.77)		23 (74.2)	8 (25.8)	1.11 (0.38-3.21)
Missing	3	2			4	1
Start of adj chemotherapy, n (%)				0.648				0.953
< 6 wk from surgery	12 (92.3)	1 (7.7)	Reference		9 (69.2)	4 (30.8)	Reference
≥ 6 wk from surgery	8 (88.8)	1 (11.1)	1.91 (0.12-30.85)		7 (77.8)	2 (22.2)	0.95 (0.18-5.13)
Missing	31	5			25	1

HR: Hazard ratio; OR: Odds ratio; CI: Confidential intervals; Adj: Adjuvant.