Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

Table 11 Demographic and patient-related preoperative potential prognostic factors for local and peritoneal recurrence

	Recurrence, n = 58
	Peritoneal				Local
	No, n = 51 (87.9%)	Yes, n = 7 (12.1%)	HR (95%CI)	P value	No, n = 41 (70.7%)	Yes, n = 17 (29.3%)	HR (95%CI)	P value
Age, yr, mean ± SD	67.6 ± 11.9	66.3 ± 14.9	0.98 (0.92-1.04)	0.489	68.6 ± 11.3	67.5 ± 14.2	0.98 (0.95-1.02)	0.345
Gender, n (%)				0.434				0.862
Male	27 (93.1)	2 (6.9)	Reference		21 (72.4)	8 (27.6)	Reference
Female	24 (82.8)	5 (17.2)	1.97 (0.36-10.77)		20 (69)	9 (31)	0.91 (0.32-2.61)
Preop Hb, g/dL, mean ± SD	11.7 ± 2.3	11.1 ± 2.7	0.91 (0.55-1.50)	0.712	11.9 ± 2.2	9.9 ± 1.9	0.71 (0.38-1.31)	0.273
Preop glycemia, g/dL, mean ± SD	1.08 ± 0.32	1.08 ± 0.41	2.42 (0.05-123.6)	0.659	1.12 ± 0.33	0.82 ± 0.16	-	0.210
Preop total proteins, g/dL, mean ± SD	7.0 ± 0.7	6.5 ± 1.1	0.17 (0.02-1.23)	0.079	6.9 ± 0.9	7.0 ± 0.4	0.60 (0.02-14.06)	0.750
Preop CEA, n (%)				0.727				0.860
< 5 ng/mL	11 (84.6)	2 (15.4)	Reference		12 (92.3)	1 (7.7)	Reference
≥ 5 ng/mL	6 (85.7)	1 (14.3)	0.52 (0.01-21.28)		5 (71.4)	2 (28.6)	1.32 (0.06-29.55)
Missing	34	4			24	14
BMI, mean ± SD	26.7 ± 4.5	30.7 ± 7.2	1.15 (0.91-1.44)	0.238	27.4 ± 5.1	26.0 ± 3.6	0.95 (0.81-1.11)	0.510
ASA, n (%)
1	4 (80)	1 (20)	Reference		4 (80)	1 (20)	Reference
2	17 (89.5)	2 (10.5)	0.25 (0.02-2.83)	0.264	15 (78.9)	4 (21.1)	0.42 (0.06-3.18)	0.401
3	18 (85.7)	3 (14.3)	0.19 (0.02-2.14)	0.178	14 (66.7)	7 (33.3)	0.35 (0.05-2.61)	0.307
4	3 (100)	0 (0)	0.47 (0.01-23.31)	0.707	1 (33.3)	2 (66.7)	2.32 (0.24-21.92)	0.464
Missing	9	1			7	3
Presentation with occlusion, n (%)				0.674				0.962
No	7 (87.5)	1 (12.5)	Reference		6 (75)	2 (25)	Reference
Yes	11 (84.6)	2 (15.4)	1.67 (0.15-18.56)		12 (92.3)	1 (7.7)	0.93 (0.06-15.21)
Missing	33	4			23	14
Tumour site, n (%)
Right colon	14 (87.5)	2 (12.5)	Reference		9 (56.3)	7 (43.7)	Reference
Left colon	24 (92.3)	2 (7.7)	0.80 (0.11-5.70)	0.825	19 (73.1)	7 (26.9)	0.79 (0.27-2.30)	0.671
Rectum	13 (81.2)	3 (18.8)	1.36 (0.23-8.17)	0.735	13 (81.3)	3 (18.7)	0.44 (0.11-1.69)	0.232

HR: Hazard ratio; OR: Odds ratio; CI: Confidential intervals; Preop: Preoperative value; Hb: Haemoglobin; CEA: Carcinoembryonic antigen; BMI: Body mass index; ASA: American Society of Anaesthesiologists Score.