Evolution and current status of the subclassification of intermediate hepatocellular carcinoma

Table 4 Kinki Criteria

BCLC substage	B1	B2	B3
Child-Pugh score	5-7	5-7	8-9
Beyond Milan and within up-to-7	In	Out	Any
			In	Out
Sub-substage			B3-a	B3-b
Concept of treatment strategy	Curative intent	Non-curative, palliative	Curative intent if within up-to-7	Palliative, no treatment
Treatment option	Resection Ablation Superselective c-TACE	DEB-TACE1 HAIC2 Sorafenib3	Transplantation Ablation Superselective c-TACE	HAIC Selective DEB-TACE
Alternative	DEB-TACE (large, C-P 7) B-TACE4	c-TACE	DEB-TACE B-TACE, HAIC	BSC

¹DEB-TACE is recommended for huge tumors that are > 6 cm;

²HAIC is recommended for multiple tumors > 6;

³Sorafenib is recommended for patients with liver function of Child-Pugh score 5 and 6;

⁴B-TACE is recommended for fewer tumors. TACE: Transcatheter arterial chemoembolization; c-TACE: Conventional subsegmental lipiodol TACE; DEB-TACE: TACE with drug-eluting beads; B-TACE: Balloon occluded TACE; HAIC: Hepatic arterial infusion chemotherapy; BSC: Best supportive care; C-P: Child-Pugh score; BCLC: Barcelona Clinic Liver Cancer.