Hyponatremia is associated with more severe biliary disease

Table 1 Bivariate and multivariate analysis of sodium level and clinical factors

		n (%)	Na (mEq/L)	Bivariate (P value)	Multivariate (P value)
Age1	< 50 yr	150 (16)	138.3	0.0001	0.821
	50-69 yr	487 (53)	136.6
	≥ 70 yr	283 (31)	135.8
Glucose1	Normal (< 115 mg/dL)	392 (44)	137.6	0.0001	0.127
	Elevated (≥ 115 mg/dL)	501 (56)	135.7
Illness severity	No infectious manifestations	403 (44)	138.7	0.0001	0.0001
	SIRS	196 (21)	136.7
	Severe	154 (17)	134.7
	Sepsis/MODS	167 (18)	133.2
Bacterial location	None/sterile	396 (45)	138.3	0.0001	0.023
	Gallstone only	60 (7)	137.2
	Bile	338 (38)	135.4
	Blood	85 (10)	133.1
Gangrenous changes	None	732 (80)	137.3	0.0001	0.002
	Gangrene	188 (20)	133.8
Charlson Co-Morbidity index1	0-2	518 (57)	137.4	0.0001	0.001
	3-4	261 (29)	136.2
	5 or more	140 (14)	134.6

¹Analyzed as a continuous variable. MODS: Multisystem organ dysfunction syndrome; SIRS: Systemic inflammatory response syndrome; Gangrenous changes: Gangrenous cholecystitis, gallbladder perforation, abscess, necrotizing pancreatitis.