Liver transplant for large hepatocellular carcinoma in Malatya: The role of gamma glutamyl transferase and alpha-fetoprotein, a retrospective cohort study

Table 4 Clinical characteristics of combination low alpha-fetoprotein/gamma glutamyl transpeptidase patients vs all other combinations

Parameters	Low AFP ≤ 200, low GGT ≤ 104, n = 14	Other combos, n = 34	P value
AFP (ng/mL)
Median	7.35	132.5	0.009b
mean ± SD	21.6 ± 32.4	758.5 ± 2397.2
GGT (IU/L)
Median	63	140.5	< 0.001c
mean ± SD	59.6 ± 31.6	208.9 ± 232.4
Total Bilirubin (mg/dL)
Median	2	1.4	0.511
mean ± SD	3.2 ± 3.8	2.5 ± 3.0
AST (IU/L)
Median	68.5	77.5	0.892
mean ± SD	126.2 ± 145.9	93.2 ± 66.4
MTD (cm)
Median	8.75	8.25	0.317
mean ± SD	8.66 ± 1.18	9.9 ± 4.5
Number of nodules, n (%)
1	8 (57)	14 (41)	0.490
> 1	6 (43)	20 (59)
Microvascular invasion, n (%)
Negative	7 (50)	7 (21)	0.041a
Positive	7 (50)	27 (79)
Differentiation, n (%)
Well	7 (50)	7 (20)	0.020a
Moderate	5 (36)	19 (56)
Poor	2 (14)	8 (24)

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

AFP: Alpha-fetoprotein; GGT: Gamma glutamyl transpeptidase; AST: Aspartate aminotransferase; MTD: Maximum dominant tumor diameter; SD: Standard deviation.