Hepatocellular carcinoma – time to take the ticket

Table 3 Criteria including tumor biomarkers

Biomarker criteria
TTV/AFP[18]	Total tumor volume ≤ 115 cm3 and AFP ≤ 400 ng/mL
AFP-TTD[37]	Total tumor diameter ≤ 8 cm and AFP ≤ 400 ng/mL
Warsaw[38]	Outside the Milan criteria but within the UCSF/ Up-to-7 criteria with AFP < 100 ng/mL
NCCK[39]	Negative PET/CT findings and the total tumor size < 10 cm
Kyoto[19]	≤ 10 tumors, all of which ≤ 5 cm in diameter, and serum DCP ≤ 400 mAU/mL
Kyushu university[40]	Tumor diameter ≤ 5 cm and serum DCP ≤ 300 mAU/mL
Extended Toronto[41]	No size-number limitation, no vascular invasion, no extrahepatic disease, no cancer-related symptoms, biopsy of the largest tumor not poorly differentiated

AFP: Alpha-fetoprotein; CT: Computed tomography; DCP: Des-gamma carboxy prothrombin; PET: Positron emission tomography; TTV: Total tumor volume.