Molecular therapeutic strategies targeting pancreatic cancer induced cachexia

doi:10.4240/wjgs.v10.i9.95

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Dec 27, 2018 (publication date) through Nov 17, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Dec 27, 2018; 10(9): 95-106
Published online Dec 27, 2018. doi: 10.4240/wjgs.v10.i9.95

Table 2 Dietary changes and observed effects in pancreatic cancer induced cachexia

Ketogenic diet	Diminishes tumor growth and induces apoptosis
Ketogenic diet	Increases skeletal muscle mass
Silibinin	Inhibits IL-6, IL-8, TNF-α secretion
	Downregulates glycolysis proteins
	Increases skeletal muscle mass
ω3 Fatty acid	Regulates metabolic dysfunction
	Lowers IL-6, TNF-α, CRP
	Improves host immune response

IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; CRP: C-reactive protein.

Citation: Yakovenko A, Cameron M, Trevino JG. Molecular therapeutic strategies targeting pancreatic cancer induced cachexia. World J Gastrointest Surg 2018; 10(9): 95-106
URL: https://www.wjgnet.com/1948-9366/full/v10/i9/95.htm
DOI: https://dx.doi.org/10.4240/wjgs.v10.i9.95