Advantage of log odds of positive lymph nodes in prognostic evaluation of patients with early-onset colon cancer

Figure 1 The flowchart of data collection and grouping for early-onset colon cancer patients. 26922 patients with ECC after radical resection of colon cancer were enrolled and randomly divided into a training group (n = 18845, 70%) and a testing group (n = 8077, 30%).

Figure 2 Nomogram for overall survival of early-onset colon cancer patients. A: Prediction for 1-, 3-, 5- and 10-year overall survival of nomogram; B and C: Calibration plots for 1-, 3- 5- and 10-year in training (B), internal validation (C). LODDS: Log odds of positive lymph node; OS: Overall survival.

Figure 3 Nomogram for cause-specific survival of early-onset colon cancer patients. A: Prediction for 1-, 3-, 5- and 10-year cause-specific survival of the nomogram; B and C: Calibration plots for 1-, 3- 5- and 10-year in training (B), internal validation (C). ECC: LODDS: Log odds of positive lymph node; CSS: Cause-specific survival.

Figure 4 Evaluation of the nomograms for overall survival of early-onset colon cancer patients with area under the curve and decision curve analysis. A and B: The time-dependent area under the curve for overall survival (OS) in the training (A) and testing (B) cohort; C and D: Decision curves for predicting 1-, 3-, 5- and 10-year OS in training (C) and testing (D) cohort. LODDS: Log odds of positive lymph node; OS: Overall survival; AUC: Area under the curve.

Figure 5 Evaluation of the nomograms for cause-specific survival of early-onset colon cancer patients with area under the curve and decision curve analysis. A and B: The time-dependent area under the curve for cause-specific survival (CSS) in the train (A) and testing (B) cohort; C and D: Decision curves for predicting 1-, 3-, 5- and 10-year CSS in training (C) and testing (D) cohort. LODDS: Log odds of positive lymph node; CSS: Cause-specific survival; AUC: Area under the curve.

Figure 6 Kaplan-Meier analyses for early-onset colon cancer patients classified by nomograms. A and B: Kaplan-Meier curves for overall survival (OS) (A) and cause-specific survival (CSS) (B) in the training cohort; C and D: Kaplan-Meier curves for OS (C) and CSS (D) in the testing cohort. LODDS: Log odds of positive lymph node.