Clinical Trials Study
Copyright ©The Author(s) 2016.
World J Diabetes. Jun 10, 2016; 7(11): 230-238
Published online Jun 10, 2016. doi: 10.4239/wjd.v7.i11.230
Table 1 Patient characteristics (n = 76)
Active GLP-1 low (n = 26)Active GLP-1 mid (n = 25)Active GLP-1 high (n = 25)P value
Sex male/female (%)828888
Age (yr)60.5 ± 13.763.8 ± 10.858.5 ± 15.3
Disease duration (yr)16.2 ± 11.215.5 ± 10.812.7 ± 10.4
FPG (mg/dL)161.1 ± 35.4160.1 ± 41.6160.7 ± 45.3
HbA1c (%)7.43 ± 1.187.44 ± 0.667.61 ± 1.32
BMI (kg/m2)22.3 ± 5.824.1 ± 10.726.8 ± 5.61
Sulfonylurea (%)545257
Biguanide (%)455276
Systolic BP (mmHg)126.8 ± 17.5133.9 ± 15.1129.2 ± 17.8
Diastolic BP (mmHg)74.5 ± 10.876.8 ± 13.678.0 ± 12.2
Proteinuria82221
γGTP (IU/L)38.5 ± 34.345.9 ± 35.543.3 ± 27.5
AST (IU/L)28.3 ± 34.022.9 ± 8.225.0 ± 10.0
ALT (IU/L)36.0 ± 60.123.9 ± 15.832.2 ± 21.3
TC (mg/dL)193.3 ± 29.6214.3 ± 32.0189.1 ± 26.0
HDLC (mg/dL)57.0 ± 16.961.6 ± 16.051.9 ± 14.3
TG (mg/dL)127.1 ± 66.3133.4 ± 132.0135.1 ± 68.5
LDLC (mg/dL)109.8 ± 26.9122.4 ± 36.5110.0 ± 24.5
UA (mg/dL)4.87 ± 0.985.22 ± 1.095.65 ± 1.271
Cr (mg/dL)0.83 ± 0.230.77 ± 0.150.75 ± 0.16
eGFR (mL/min)76.7 ± 21.378.8 ± 17.783.1 ± 19.3
Table 2 Logistic regression analysis to identify the factors associated with the efficacy of sitgliptin (dA1c ≥ 0.5%)
VariablesUnivariate
Model 1
Model 2
Model 3
Model 4
Model 5
OR (95%CI)P valueOR (95%CI)P valueOR (95%CI)P valueOR (95%CI)P valueOR (95%CI)P valueOR (95%CI)P value
GLP-1 not high group4.50 (1.40-17.6)0.015.72 (1.64-25.99)0.014.93 (1.07-32.96)0.047.66 (1.48-57.48)0.018.04 (1.30-75.83)0.025.83 (1.12-45.6)0.04
HbA1c (%)1.81 (1.32-2.6)0.0011.69 (1.03-3.02)0.042.30 (1.11-5.63)0.022.23 (1.02-5.59)0.052.63 (1.19-6.88)0.022.51 (1.04-7.05)0.04
FPG (mg/dL)1.01 (1.00-1.02)0.003
Sex (male)1.85 (0.73-4.65)0.195.69 (0.73-57.54)0.14.39 (0.51-47.1)0.185.53 (0.46-92.72)0.186.97 (0.78-90.5)0.08
Age (yr)1.00 (0.97-1.02)0.770.98 (0.91-1.05)0.530.96 (0.88-1.03)0.260.99 (0.92-1.08)0.890.97 (0.90-1.05)0.48
Duration (yr)1.03 (1.00-1.07)0.091.01 (0.95-1.09)0.731.01 (0.94-1.09)0.771.03 (0.95-1.13)0.440.67
BMI (kg/m2)0.92 (0.83-0.99)0.050.70 (0.50-0.91)0.0030.64 (0.43-0.86)0.0010.63 (0.39-0.90)0.010.66 (0.43-0.92)0.01
Sulfonylurea (+)1.25 (0.63-2.46)0.531.15 (0.22-6.13)0.87
Biguanide (+)2.83 (1.42-5.76)0.0030.18 (0.02-1.01)0.05
Plasma insulin (μU/mL)0.9 (0.82-0.98)0.011.25 (0.94-1.69]0.12
C peptide (ng/mL)0.8 (0.55-1.11)0.19
PI/IRI1.33 (0.78-2.6)0.294.94 (0.54-99.3)0.17
Glcagon (pg/mL)0.99 (0.97-1.00)0.110.97 (0.18-4.63)0.97
Log (hsCRP) [log (mg/mL)]1.03 (0.53-1.98)0.920.98 (0.94-1.01)0.21
HOMA-β0.97 (0.95-0.99)0.011.02 (0.94-1.09)0.67
HOMA-IR0.83 (0.67-0.99)0.0040.98 (0.45-2.15)0.96