Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers

Table 1 Characteristics of subjects

Characteristics	Median (interquartile range)
Number (male/female)	12 (6/6)
Age (yr)	24 (23-25)
BMI (kg/m2)	21.6 (20.7-23.7)
Waist (cm)	74.5 (66.3-80.0)
Blood pressure (mmHg)	113/75 (107/66-117/80)
Fasting plasma glucose (mmol/L)	4.7 (4.6-5.3)
Plasma triglycerides (mmol/L)	0.8 (0.7-0.9)
HDL cholesterol (mmol/L)	1.4 (1.1-1.6)
LDL cholesterol (mmol/L)	2.5 (2.3-3.1)
Fibrinogen (mmol/L)	2.3 (2.2-2.5)

BMI: Body mass index; HDL: High-density lipoprotein; LDL: Low-density lipoprotein.

Table 2 Results are summarized in three groups

	Basal	50 mIU/L	150 mIU/L
Measured insulin level (mIU/L)	3.5	47.5b	144.5b
	(1.8-4.1)	(36.0-53.3)	(115.9-170.5)
LDF baseline (PU)	7.5	12.3	12.9
	(6.8-10.2)	(9.2-21.8)	(8.6-29.9)
LDF heating test (%)	1599	1848a	1937b
	(801-1836)	(984-2046)	(1177-2488)
LDF post-occlusion	4.9	1.2a	1.0b
Hyperemia test (s)	(1.8-11.4)	(0.9-2.6)	(0.7-1.1)
tcpO2 (mmHg)	38.9	48.6a	57.4a
	(35.5-40.8)	(45.5-49.7)	(51.7-66.2)

Data are expressed as median (interquartile range.

^aP < 0.05,

^bP < 0.01 vs basal group. LDF: Laser Doppler flowmetry.