Protective effect of liraglutide on the myocardium of type 2 diabetic rats by inhibiting polyadenosine diphosphate-ribose polymerase-1

doi:10.4239/wjd.v14.i2.110

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Feb 15, 2023 (publication date) through May 31, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Feb 15, 2023; 14(2): 110-119
Published online Feb 15, 2023. doi: 10.4239/wjd.v14.i2.110

Table 1 Comparison of body weight and heart weight index of rats in each group (mean ± SD)

Group	Weight	Heart weight index
N	381 ± 22.5	2.58 ± 0.28
M	476.2 ± 27.5^a	4.46 ± 0.31^a
LL	451.5 ± 10.4^a^b	3.98 ± 0.26^a^b
HL	430.1 ± 13.5^a^b^c	3.03 ± 0.33^a^b^c

^aP < 0.05, compared with group N.

^bP < 0.05, compared with group M.

^cP < 0.05, compared with group LL.

N: Normal control; M: Model; HL: High-dose liraglutide; LL: Low-dose liraglutide.

Table 2 Comparison of blood glucose and blood lipids of rats in each group (mean ± SD)

Group	FBG	TG	TC	LDL	HDL	LP
N	5.7 ± 0.9	1.2 ± 0.28	1.73 ± 0.44	0.66 ± 0.25	1.5 ± 0.57	298 ± 41
M	25.9 ± 2.8^a	2.84 ± 0.56^a	4.27 ± 0.56^a	5.49 ± 2.37^a	1.05 ± 0.19	667 ± 79^a
LL	20.9 ± 1.1^a^b	2.24 ± 0.52^a^b	3.32 ± 0.7^a^b	3.56 ± 0.73^a^b	1.1 ± 0.2	549 ± 45^a^b
HL	18.9 ± 1.3^a^b^c	1.67 ± 0.39^a^b^c	2.66 ± 0.76^a^b^c	2.06 ± 0.77^a^b^c	1.42 ± 0.64	448 ± 130^a^b^c

^aP < 0.05, compared with group N.

^bP < 0.05, compared with group M.

^cP < 0.05, compared with group LL.

N: Normal control; M: Model; HL: High-dose liraglutide; LL: Low-dose liraglutide. FBG: Fasting blood glucose; TG: Triglyceride; TC: Total cholesterol; LDL: Low density lipoprotein; HDL: High density lipoprotein; LP: Lipoprotein.

Table 3 Expression of polyadenosine diphosphate-ribose polymerase-1 in myocardial tissue of rats in each group (mean ± SD)

Group	Number	PARP-1
N	8	10.92 ± 3.59
M	8	58.12 ± 5.31^a
LL	8	42.83 ± 1.14^a^b
HL	8	23.61 ± 0.92^a^b^c

^aP < 0.05, compared with group N.

^bP < 0.05, compared with group M.

^cP < 0.05, compared with group LL.

PARP-1: Polyadenosine diphosphate-ribose polymerase-1; N: Normal control; M: Model; HL: High-dose liraglutide; LL: Low-dose liraglutide.

Citation: Xue DD, Zhang X, Li DW, Yang YL, Liu JJ. Protective effect of liraglutide on the myocardium of type 2 diabetic rats by inhibiting polyadenosine diphosphate-ribose polymerase-1. World J Diabetes 2023; 14(2): 110-119
URL: https://www.wjgnet.com/1948-9358/full/v14/i2/110.htm
DOI: https://dx.doi.org/10.4239/wjd.v14.i2.110