Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese

doi:10.4239/wjd.v13.i8.643

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Aug 15, 2022 (publication date) through May 31, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Diabetes. Aug 15, 2022; 13(8): 643-653
Published online Aug 15, 2022. doi: 10.4239/wjd.v13.i8.643

Table 1 Domain boundaries and score for each of the domains

Source	Domain	Start	End	Gathering threshold (bits)		Score (bits)		E-value
Source	Domain	Start	End	Sequence	Domain	Sequence	Domain	Sequence	Domain
Pfam	ObR_Ig	126	233	25.8	25.8	170.5	61.1	3.50E-47	3.9E-13
Pfam	Lep_receptor_Ig	329	420	28.8	28.8	84.8	84.8	1.00E-20	1.00E-20
Pfam	ObR_Ig	431	533	25.8	25.8	170.5	112.7	3.50E-47	3.40E-29
Transmembrane	NA	840	862	NA	NA	NA	NA	NA	NA
Low_complexity	NA	849	863	NA	NA	NA	NA	NA	NA
Disorder	NA	924	927	NA	NA	NA	NA	NA	NA
Low_complexity	NA	937	946	NA	NA	NA	NA	NA	NA
Disorder	NA	966	967	NA	NA	NA	NA	NA	NA
Disorder	NA	970	973	NA	NA	NA	NA	NA	NA
Disorder	NA	975	976	NA	NA	NA	NA	NA	NA
Disorder	NA	997	1001	NA	NA	NA	NA	NA	NA
Disorder	NA	1064	1065	NA	NA	NA	NA	NA	NA

NA: No adoption.

Table 2 Baseline characteristics

		Control, n = 908	HTN, n = 1061	HTN with T2DM, n = 683	P value
		Control, n = 908	HTN, n = 1061	HTN with T2DM, n = 683	Control vs HTN	Control vs HTN + T2DM	HTN vs HTN + T2DM
Ethnic	Han	455	406	486	< 0.0001	< 0.0001	< 0.0001
Ethnic	Mongolian	453	655	197	< 0.0001	< 0.0001	< 0.0001
Gender	Male	357	601	397	< 0.0001	< 0.0001	0.542
Gender	Female	551	460	286	< 0.0001	< 0.0001	0.542
Age		48.11 ± 15.06	54.49 ± 15.67	63.89 ± 11.17	< 0.0001	< 0.0001	< 0.0001
Weight (kg)		66.14 ± 11.06	72.32 ± 12.06	73.35 ± 12.48	< 0.0001	< 0.0001	0.2156
Height (cm)		163 ± 0.09	168 ± 0.08	161.26 ± 0.10	< 0.0001	0.6110	0.0032
BMI (kg/m²)		25.27 ± 8.50	25.56 ± 3.63	26.48 ± 5.12	0.4067	0.7588	0.8723
FBS (mmol/L)		5.06 ± 0.49	5.73 ± 0.77	8.59 ± 3.37	0.0721	< 0.0001	< 0.0001
SBP (mm Hg)		117.21 ± 14.27	151.10 ± 18.94	166.47 ± 17.53	< 0.0001	< 0.0001	< 0.0001
DBP (mm Hg)		77.20 ± 7.95	88.59 ± 12.74	100.84 ± 13.31	< 0.0001	< 0.0001	< 0.0001
TG (mmol/L)		1.63 ± 1.06	2.24 ± 1.52	2.59 ± 12.14	0.0626	0.0051	0.4768
CHO (mmol/L)		4.53 ± 1.30	4.47 ± 3.59	4.52 ± 1.26	0.8913	0.9984	0.8885
HDL (mmol/L)		1.44 ± 0.54	1.75 ± 0.95	1.27 ± 0.35	< 0.0001	< 0.0001	< 0.0001
LDL (mmol/L)		2.84 ± 1.00	2.87 ± 1.38	2.94 ± 11.1	0.9921	0.9225	0.9586

Data presented as mean ± SD and percentages. P value of < 0.05 was considered significant. BMI: Body mass index; FBS: Fasting blood sugar; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; TG: Triglyceride; CHO: Cholesterol; HDL: High density lipoprotein; LDL: Low density lipoprotein; HTN: Hypertension; T2DM: Type 2 diabetes mellitus.

Table 3 Hardy Weinberg equilibrium analysis

	Group	G/G	G/A	A/A	G	A	P value
Han, n = 1347	Control, n = 455	351	94	10	796	114	0.2
	HTN, n = 406	312	91	3	715	97	0.24
	HTN + T2DM, n = 486	394	84	8	872	100	0.21
Mongolian, n = 1305	Control, n = 453	343	101	9	787	119	0.68
	HTN, n = 655	436	202	17	1074	236	0.29
	HTN + T2DM, n = 197	151	42	4	344	50	0.53

P value of < 0.05 was considered significant. HTN: Hypertension; T2DM: Type 2 diabetes mellitus.

Table 4 Statistics of allele and genotype frequencies

Population	Allele	All subjects count (%)	Control count (%)	HTN count (%)	HTN + T2DM count (%)	P value
Han, n = 1347	G	2383 (88)	796 (87)	715 (88)	872 (90)	0.288
	A	311 (12)	114 (13)	97 (12)	100 (10)	0.288
	A/A	21 (2)	10 (2)	3 (1)	8 (2)	0.153
	G/A	269 (20)	94 (21)	91 (22)	84 (17)
	G/G	1057 (78)	351 (77)	312 (77)	394 (81)
Mongolian, n = 1305	G	2205 (84)	787 (87)	1074 (82)	344 (87)	0.002
	A	405 (16)	119 (13)	236 (18)	50 (13)	0.002
	A/A	30 (2)	9 (2)	17 (3)	4 (2)	0.006
	G/A	345 (26)	101 (22)	202 (31)	42 (21)
	G/G	930 (71)	343 (76)	436 (67)	151 (77)

P value of < 0.05 was considered significant. HTN: Hypertension; T2DM: Type 2 diabetes mellitus.

Table 5 Association of the control and hypertension groups for Han and Mongolian Chinese

Model	Genotype	Han, n = 861				Mongolian, n = 1108
Model	Genotype	Control, n (%)	HTN, n (%)	OR (95%CI)	P value	Control, n (%)	HTN, n (%)	OR (95%CI)	P value
Co-dominant	G/G	351 (77.1)	312 (76.8)	1	0.041	343 (75.7)	436 (66.6)	1	0.016
	A/G	94 (20.7)	91 (22.4)	0.88 (0.62-1.27)		101 (22.3)	202 (30.8)	1.49 (1.12-1.97)
	A/A	10 (2.2)	3 (0.7)	0.21 (0.05-0.80)		9 (2.0)	17 (2.6)	1.47 (0.64-3.34)
Dominant	G/G	351 (77.1)	312 (76.8)	1	0.23	343 (75.7)	436 (66.6)	1	0.004
Dominant	A/G-A/A	104 (22.9)	94 (23.1)	0.81 (0.57-1.15)	0.23	110 (24.3)	219 (33.4)	1.49 (1.13-1.95)	0.004
Recessive	G/G-A/G	445 (97.8)	403 (99.3)	1	0.015	444 (98)	638 (97.4)	1	0.51
Recessive	A/A	10 (2.2)	3 (0.7)	0.21 (0.05-0.82)	0.015	9 (2.0)	17 (2.6)	1.32 (0.58-2.99)	0.51
Over-dominant	G/G-A/A	361 (79.3)	315 (77.6)	1	0.63	352 (77.7)	453 (69.2)	1	0.0064
Over-dominant	A/G	94 (20.7)	91 (22.4)	0.91 (0.64-1.31)	0.63	101 (22.3)	202 (30.8)	1.47 (1.11-1.95)	0.0064
Log-additive	-	-	-	0.75 (0.55-1.04)	0.082	-	-	1.40 (1.10-1.79)	0.0059

Adjusted for sex and age. P value of < 0.05 was considered significant. HTN: Hypertension; OR: Odd ratio; CI: Confidence interval.

Table 6 Association of rs1137101 with hypertension + type 2 diabetes mellitus (control vs hypertension + type 2 diabetes mellitus)

Model	Genotype	Han, n = 941				Mongolian, n = 650
Model	Genotype	Control, n (%)	HTN with T2DM, n (%)	OR (95%CI)	P value	Control, n (%)	HTN with T2DM, n (%)	OR (95%CI)	P value
Co-dominant	G/G	351 (77.1)	394 (81.1)	1	0.0075	343 (75.7)	151 (76.7)	1	0.3
	A/G	94 (20.7)	84 (17.3)	0.59 (0.40-0.87)		101 (22.3)	42 (21.3)	0.70 (0.44-1.11)
	A/A	10 (2.2)	8 (1.6)	0.38 (0.14-1.08)		9 (2.0)	4 (2.0)	1.06 (0.27-4.25)
Dominant	G/G	351 (77.1)	394 (81.1)	1	0.0024	343 (75.7)	151 (76.7)	1	0.15
Dominant	A/G-A/A	104 (22.9)	92 (18.9)	0.56 (0.39-0.82)	0.0024	110 (24.3)	46 (23.4)	0.72 (0.46-1.13)	0.15
Recessive	G/G-A/G	445 (97.8)	478 (98.3)	1	0.11	444 (98.0)	193 (98.0)	1	0.84
Recessive	A/A	10 (2.2)	8 (1.6)	0.43 (0.15-1.21)	0.11	9 (2.0)	4 (2.0)	1.15 (0.29-4.57)	0.84
Over-dominant	G/G-A/A	361 (79.3)	402 (82.7)	1	0.01	352 (77.7)	155 (78.7)	1	0.12
Over-dominant	A/G	94 (20.7)	84 (17.3)	0.61 (0.41-0.89)	0.01	101 (22.3)	42 (21.3)	0.70 (0.44-1.11)	0.12
Log-additive	-	-	-	0.60 (0.43-0.83)	0.0018	-	-	0.78 (0.52-1.16)	0.22

Adjusted for sex and age. P value of < 0.05 was considered significant. OR: Odd ratio; HTN: Hypertension; T2DM: Type 2 diabetes mellitus; CI: Confidence interval.

Table 7 Association of rs1137101 with hypertension and type 2 diabetes mellitus (hypertension and hypertension + type 2 diabetes mellitus)

Model	Genotype	Han, n = 892				Mongolian, n = 852
Model	Genotype	Control, n (%)	HTN with T2DM, n (%)	OR (95%CI)	P value	Control, n (%)	HTN with T2DM, n (%)	OR (95%CI)	P value
Co-dominant	G/G	312 (76.8)	394 (81.1)	1	0.034	436 (66.6)	151 (76.7)	1	0.0067
	A/G	91 (22.4)	84 (17.3)	0.65 (0.46-0.92)		202 (30.8)	42 (21.3)	0.54 (0.36-0.81)
	A/A	3 (0.7)	8 (1.6)	1.61 (0.41-6.28)		17 (2.6)	4 (2.0)	0.55 (0.17-1.79)
Dominant	G/G	312 (76.8)	394 (81.1)	1	0.026	436 (66.6)	151 (76.7)	1	0.0016
Dominant	A/G-A/A	94 (23.1)	92 (18.9)	0.68 (0.49-0.96)	0.026	219 (33.4)	46 (23.4)	0.54 (0.36-0.80)	0.0016
Recessive	G/G-A/G	403 (99.3)	478 (98.3)	1	0.39	638 (97.4)	193 (98.0)	1	0.46
Recessive	A/A	3 (0.7)	8 (1.6)	1.77 (0.46-6.87)	0.39	17 (2.6)	4 (2.0)	0.65 (0.20-2.11)	0.46
Over-dominant	G/G-A/A	315 (77.6)	402 (82.7)	1	0.012	453 (69.2)	155 (78.7)	1	0.0028
Over-dominant	A/G	91 (22.4)	84 (17.3)	0.65 (0.46-0.91)	0.012	202 (30.8)	42 (21.3)	0.55 (0.37-0.82)	0.0028
Log-additive	-	-	-	0.75 (0.55-1.02)	0.067	-	-	0.59 (0.41-0.84)	0.0024

Adjusted for sex and age. P value of < 0.05 was considered significant. OR: Odd ratio; HTN: Hypertension; T2DM: Type 2 diabetes mellitus; CI: Confidence interval.

Citation: Zhao KY, Yuan ML, Wu YN, Cui HW, Han WY, Wang J, Su XL. Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese. World J Diabetes 2022; 13(8): 643-653
URL: https://www.wjgnet.com/1948-9358/full/v13/i8/643.htm
DOI: https://dx.doi.org/10.4239/wjd.v13.i8.643