Zhao KY, Yuan ML, Wu YN, Cui HW, Han WY, Wang J, Su XL. Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese. World J Diabetes 2022; 13(8): 643-653 [PMID: 36159223 DOI: 10.4239/wjd.v13.i8.643]
Corresponding Author of This Article
Xiu-Lan Su, MMed, Professor, Clinical Medical Research Center of The Affiliated Hospital, Inner Mongolia Key Laboratory of Medical Cellular Biology, Inner Mongolia Medical University, No. 1 North Tongdao Road, Hohhot, 010050, Inner Mongolia Autonomous Region, China. xlsu@sina.com
Research Domain of This Article
Genetics & Heredity
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Aug 15, 2022; 13(8): 643-653 Published online Aug 15, 2022. doi: 10.4239/wjd.v13.i8.643
Table 1 Domain boundaries and score for each of the domains
Source
Domain
Start
End
Gathering threshold (bits)
Score (bits)
E-value
Sequence
Domain
Sequence
Domain
Sequence
Domain
Pfam
ObR_Ig
126
233
25.8
25.8
170.5
61.1
3.50E-47
3.9E-13
Pfam
Lep_receptor_Ig
329
420
28.8
28.8
84.8
84.8
1.00E-20
1.00E-20
Pfam
ObR_Ig
431
533
25.8
25.8
170.5
112.7
3.50E-47
3.40E-29
Transmembrane
NA
840
862
NA
NA
NA
NA
NA
NA
Low_complexity
NA
849
863
NA
NA
NA
NA
NA
NA
Disorder
NA
924
927
NA
NA
NA
NA
NA
NA
Low_complexity
NA
937
946
NA
NA
NA
NA
NA
NA
Disorder
NA
966
967
NA
NA
NA
NA
NA
NA
Disorder
NA
970
973
NA
NA
NA
NA
NA
NA
Disorder
NA
975
976
NA
NA
NA
NA
NA
NA
Disorder
NA
997
1001
NA
NA
NA
NA
NA
NA
Disorder
NA
1064
1065
NA
NA
NA
NA
NA
NA
Table 2 Baseline characteristics
Control, n = 908
HTN, n = 1061
HTN with T2DM, n = 683
P value
Control vs HTN
Control vs HTN + T2DM
HTN vs HTN + T2DM
Ethnic
Han
455
406
486
< 0.0001
< 0.0001
< 0.0001
Mongolian
453
655
197
Gender
Male
357
601
397
< 0.0001
< 0.0001
0.542
Female
551
460
286
Age
48.11 ± 15.06
54.49 ± 15.67
63.89 ± 11.17
< 0.0001
< 0.0001
< 0.0001
Weight (kg)
66.14 ± 11.06
72.32 ± 12.06
73.35 ± 12.48
< 0.0001
< 0.0001
0.2156
Height (cm)
163 ± 0.09
168 ± 0.08
161.26 ± 0.10
< 0.0001
0.6110
0.0032
BMI (kg/m2)
25.27 ± 8.50
25.56 ± 3.63
26.48 ± 5.12
0.4067
0.7588
0.8723
FBS (mmol/L)
5.06 ± 0.49
5.73 ± 0.77
8.59 ± 3.37
0.0721
< 0.0001
< 0.0001
SBP (mm Hg)
117.21 ± 14.27
151.10 ± 18.94
166.47 ± 17.53
< 0.0001
< 0.0001
< 0.0001
DBP (mm Hg)
77.20 ± 7.95
88.59 ± 12.74
100.84 ± 13.31
< 0.0001
< 0.0001
< 0.0001
TG (mmol/L)
1.63 ± 1.06
2.24 ± 1.52
2.59 ± 12.14
0.0626
0.0051
0.4768
CHO (mmol/L)
4.53 ± 1.30
4.47 ± 3.59
4.52 ± 1.26
0.8913
0.9984
0.8885
HDL (mmol/L)
1.44 ± 0.54
1.75 ± 0.95
1.27 ± 0.35
< 0.0001
< 0.0001
< 0.0001
LDL (mmol/L)
2.84 ± 1.00
2.87 ± 1.38
2.94 ± 11.1
0.9921
0.9225
0.9586
Table 3 Hardy Weinberg equilibrium analysis
Group
G/G
G/A
A/A
G
A
P value
Han, n = 1347
Control, n = 455
351
94
10
796
114
0.2
HTN, n = 406
312
91
3
715
97
0.24
HTN + T2DM, n = 486
394
84
8
872
100
0.21
Mongolian, n = 1305
Control, n = 453
343
101
9
787
119
0.68
HTN, n = 655
436
202
17
1074
236
0.29
HTN + T2DM, n = 197
151
42
4
344
50
0.53
Table 4 Statistics of allele and genotype frequencies
Population
Allele
All subjects count (%)
Control count (%)
HTN count (%)
HTN + T2DM count (%)
P value
Han, n = 1347
G
2383 (88)
796 (87)
715 (88)
872 (90)
0.288
A
311 (12)
114 (13)
97 (12)
100 (10)
A/A
21 (2)
10 (2)
3 (1)
8 (2)
0.153
G/A
269 (20)
94 (21)
91 (22)
84 (17)
G/G
1057 (78)
351 (77)
312 (77)
394 (81)
Mongolian, n = 1305
G
2205 (84)
787 (87)
1074 (82)
344 (87)
0.002
A
405 (16)
119 (13)
236 (18)
50 (13)
A/A
30 (2)
9 (2)
17 (3)
4 (2)
0.006
G/A
345 (26)
101 (22)
202 (31)
42 (21)
G/G
930 (71)
343 (76)
436 (67)
151 (77)
Table 5 Association of the control and hypertension groups for Han and Mongolian Chinese
Model
Genotype
Han, n = 861
Mongolian, n = 1108
Control, n (%)
HTN, n (%)
OR (95%CI)
P value
Control, n (%)
HTN, n (%)
OR (95%CI)
P value
Co-dominant
G/G
351 (77.1)
312 (76.8)
1
0.041
343 (75.7)
436 (66.6)
1
0.016
A/G
94 (20.7)
91 (22.4)
0.88 (0.62-1.27)
101 (22.3)
202 (30.8)
1.49 (1.12-1.97)
A/A
10 (2.2)
3 (0.7)
0.21 (0.05-0.80)
9 (2.0)
17 (2.6)
1.47 (0.64-3.34)
Dominant
G/G
351 (77.1)
312 (76.8)
1
0.23
343 (75.7)
436 (66.6)
1
0.004
A/G-A/A
104 (22.9)
94 (23.1)
0.81 (0.57-1.15)
110 (24.3)
219 (33.4)
1.49 (1.13-1.95)
Recessive
G/G-A/G
445 (97.8)
403 (99.3)
1
0.015
444 (98)
638 (97.4)
1
0.51
A/A
10 (2.2)
3 (0.7)
0.21 (0.05-0.82)
9 (2.0)
17 (2.6)
1.32 (0.58-2.99)
Over-dominant
G/G-A/A
361 (79.3)
315 (77.6)
1
0.63
352 (77.7)
453 (69.2)
1
0.0064
A/G
94 (20.7)
91 (22.4)
0.91 (0.64-1.31)
101 (22.3)
202 (30.8)
1.47 (1.11-1.95)
Log-additive
-
-
-
0.75 (0.55-1.04)
0.082
-
-
1.40 (1.10-1.79)
0.0059
Table 6 Association of rs1137101 with hypertension + type 2 diabetes mellitus (control vs hypertension + type 2 diabetes mellitus)
Model
Genotype
Han, n = 941
Mongolian, n = 650
Control, n (%)
HTN with T2DM, n (%)
OR (95%CI)
P value
Control, n (%)
HTN with T2DM, n (%)
OR (95%CI)
P value
Co-dominant
G/G
351 (77.1)
394 (81.1)
1
0.0075
343 (75.7)
151 (76.7)
1
0.3
A/G
94 (20.7)
84 (17.3)
0.59 (0.40-0.87)
101 (22.3)
42 (21.3)
0.70 (0.44-1.11)
A/A
10 (2.2)
8 (1.6)
0.38 (0.14-1.08)
9 (2.0)
4 (2.0)
1.06 (0.27-4.25)
Dominant
G/G
351 (77.1)
394 (81.1)
1
0.0024
343 (75.7)
151 (76.7)
1
0.15
A/G-A/A
104 (22.9)
92 (18.9)
0.56 (0.39-0.82)
110 (24.3)
46 (23.4)
0.72 (0.46-1.13)
Recessive
G/G-A/G
445 (97.8)
478 (98.3)
1
0.11
444 (98.0)
193 (98.0)
1
0.84
A/A
10 (2.2)
8 (1.6)
0.43 (0.15-1.21)
9 (2.0)
4 (2.0)
1.15 (0.29-4.57)
Over-dominant
G/G-A/A
361 (79.3)
402 (82.7)
1
0.01
352 (77.7)
155 (78.7)
1
0.12
A/G
94 (20.7)
84 (17.3)
0.61 (0.41-0.89)
101 (22.3)
42 (21.3)
0.70 (0.44-1.11)
Log-additive
-
-
-
0.60 (0.43-0.83)
0.0018
-
-
0.78 (0.52-1.16)
0.22
Table 7 Association of rs1137101 with hypertension and type 2 diabetes mellitus (hypertension and hypertension + type 2 diabetes mellitus)
Model
Genotype
Han, n = 892
Mongolian, n = 852
Control, n (%)
HTN with T2DM, n (%)
OR (95%CI)
P value
Control, n (%)
HTN with T2DM, n (%)
OR (95%CI)
P value
Co-dominant
G/G
312 (76.8)
394 (81.1)
1
0.034
436 (66.6)
151 (76.7)
1
0.0067
A/G
91 (22.4)
84 (17.3)
0.65 (0.46-0.92)
202 (30.8)
42 (21.3)
0.54 (0.36-0.81)
A/A
3 (0.7)
8 (1.6)
1.61 (0.41-6.28)
17 (2.6)
4 (2.0)
0.55 (0.17-1.79)
Dominant
G/G
312 (76.8)
394 (81.1)
1
0.026
436 (66.6)
151 (76.7)
1
0.0016
A/G-A/A
94 (23.1)
92 (18.9)
0.68 (0.49-0.96)
219 (33.4)
46 (23.4)
0.54 (0.36-0.80)
Recessive
G/G-A/G
403 (99.3)
478 (98.3)
1
0.39
638 (97.4)
193 (98.0)
1
0.46
A/A
3 (0.7)
8 (1.6)
1.77 (0.46-6.87)
17 (2.6)
4 (2.0)
0.65 (0.20-2.11)
Over-dominant
G/G-A/A
315 (77.6)
402 (82.7)
1
0.012
453 (69.2)
155 (78.7)
1
0.0028
A/G
91 (22.4)
84 (17.3)
0.65 (0.46-0.91)
202 (30.8)
42 (21.3)
0.55 (0.37-0.82)
Log-additive
-
-
-
0.75 (0.55-1.02)
0.067
-
-
0.59 (0.41-0.84)
0.0024
Citation: Zhao KY, Yuan ML, Wu YN, Cui HW, Han WY, Wang J, Su XL. Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese. World J Diabetes 2022; 13(8): 643-653