Case Control Study
Copyright ©The Author(s) 2022.
World J Diabetes. Aug 15, 2022; 13(8): 643-653
Published online Aug 15, 2022. doi: 10.4239/wjd.v13.i8.643
Table 1 Domain boundaries and score for each of the domains
SourceDomainStartEndGathering threshold (bits)
Score (bits)
E-value
Sequence
Domain
Sequence
Domain
Sequence
Domain
PfamObR_Ig12623325.825.8170.561.13.50E-473.9E-13
PfamLep_receptor_Ig32942028.828.884.884.81.00E-201.00E-20
PfamObR_Ig43153325.825.8170.5112.73.50E-473.40E-29
TransmembraneNA840862NANANANANANA
Low_complexityNA849863NANANANANANA
DisorderNA924927NANANANANANA
Low_complexityNA937946NANANANANANA
DisorderNA966967NANANANANANA
DisorderNA970973NANANANANANA
DisorderNA975976NANANANANANA
DisorderNA9971001NANANANANANA
DisorderNA10641065NANANANANANA
Table 2 Baseline characteristics
Control, n = 908HTN, n = 1061HTN with T2DM, n = 683
P value
Control vs HTN
Control vs HTN + T2DM
HTN vs HTN + T2DM
EthnicHan455406486< 0.0001< 0.0001< 0.0001
Mongolian453655197
GenderMale357601397< 0.0001< 0.00010.542
Female551460286
Age48.11 ± 15.0654.49 ± 15.6763.89 ± 11.17< 0.0001< 0.0001< 0.0001
Weight (kg)66.14 ± 11.0672.32 ± 12.0673.35 ± 12.48< 0.0001< 0.00010.2156
Height (cm)163 ± 0.09168 ± 0.08161.26 ± 0.10< 0.00010.61100.0032
BMI (kg/m2)25.27 ± 8.5025.56 ± 3.6326.48 ± 5.120.40670.75880.8723
FBS (mmol/L)5.06 ± 0.495.73 ± 0.778.59 ± 3.370.0721< 0.0001< 0.0001
SBP (mm Hg)117.21 ± 14.27151.10 ± 18.94166.47 ± 17.53< 0.0001< 0.0001< 0.0001
DBP (mm Hg)77.20 ± 7.9588.59 ± 12.74100.84 ± 13.31< 0.0001< 0.0001< 0.0001
TG (mmol/L)1.63 ± 1.062.24 ± 1.522.59 ± 12.140.06260.00510.4768
CHO (mmol/L)4.53 ± 1.304.47 ± 3.594.52 ± 1.260.89130.99840.8885
HDL (mmol/L)1.44 ± 0.541.75 ± 0.951.27 ± 0.35< 0.0001< 0.0001< 0.0001
LDL (mmol/L)2.84 ± 1.002.87 ± 1.382.94 ± 11.10.99210.92250.9586
Table 3 Hardy Weinberg equilibrium analysis

Group
G/G
G/A
A/A
G
A
P value
Han, n = 1347Control, n = 45535194107961140.2
HTN, n = 406312913715970.24
HTN + T2DM, n = 4863948488721000.21
Mongolian, n = 1305Control, n = 45334310197871190.68
HTN, n = 6554362021710742360.29
HTN + T2DM, n = 197151424344500.53
Table 4 Statistics of allele and genotype frequencies
Population
Allele
All subjects count (%)
Control count (%)
HTN count (%)
HTN + T2DM count (%)
P value
Han, n = 1347G2383 (88)796 (87)715 (88)872 (90)0.288
A311 (12)114 (13)97 (12)100 (10)
A/A21 (2)10 (2)3 (1)8 (2)0.153
G/A269 (20)94 (21)91 (22)84 (17)
G/G1057 (78)351 (77)312 (77)394 (81)
Mongolian, n = 1305G2205 (84)787 (87)1074 (82)344 (87)0.002
A405 (16)119 (13)236 (18)50 (13)
A/A30 (2)9 (2)17 (3)4 (2)0.006
G/A345 (26)101 (22)202 (31)42 (21)
G/G930 (71)343 (76)436 (67)151 (77)
Table 5 Association of the control and hypertension groups for Han and Mongolian Chinese
ModelGenotypeHan, n = 861
Mongolian, n = 1108
Control, n (%)
HTN, n (%)
OR (95%CI)
P value
Control, n (%)
HTN, n (%)
OR (95%CI)
P value
Co-dominantG/G351 (77.1)312 (76.8)10.041343 (75.7)436 (66.6)10.016
A/G94 (20.7)91 (22.4)0.88 (0.62-1.27)101 (22.3)202 (30.8)1.49 (1.12-1.97)
A/A10 (2.2)3 (0.7)0.21 (0.05-0.80)9 (2.0)17 (2.6)1.47 (0.64-3.34)
DominantG/G351 (77.1)312 (76.8)10.23343 (75.7)436 (66.6)10.004
A/G-A/A104 (22.9)94 (23.1)0.81 (0.57-1.15)110 (24.3)219 (33.4)1.49 (1.13-1.95)
RecessiveG/G-A/G445 (97.8)403 (99.3)10.015444 (98)638 (97.4)10.51
A/A10 (2.2)3 (0.7)0.21 (0.05-0.82)9 (2.0)17 (2.6)1.32 (0.58-2.99)
Over-dominantG/G-A/A361 (79.3)315 (77.6)10.63352 (77.7)453 (69.2)10.0064
A/G94 (20.7)91 (22.4)0.91 (0.64-1.31)101 (22.3)202 (30.8)1.47 (1.11-1.95)
Log-additive---0.75 (0.55-1.04)0.082--1.40 (1.10-1.79)0.0059
Table 6 Association of rs1137101 with hypertension + type 2 diabetes mellitus (control vs hypertension + type 2 diabetes mellitus)
ModelGenotypeHan, n = 941
Mongolian, n = 650
Control, n (%)
HTN with T2DM, n (%)
OR (95%CI)
P value
Control, n (%)
HTN with T2DM, n (%)
OR (95%CI)
P value
Co-dominantG/G351 (77.1)394 (81.1)10.0075343 (75.7)151 (76.7)10.3
A/G94 (20.7)84 (17.3)0.59 (0.40-0.87)101 (22.3)42 (21.3)0.70 (0.44-1.11)
A/A10 (2.2)8 (1.6)0.38 (0.14-1.08)9 (2.0)4 (2.0)1.06 (0.27-4.25)
DominantG/G351 (77.1)394 (81.1)10.0024343 (75.7)151 (76.7)10.15
A/G-A/A104 (22.9)92 (18.9)0.56 (0.39-0.82)110 (24.3)46 (23.4)0.72 (0.46-1.13)
RecessiveG/G-A/G445 (97.8)478 (98.3)10.11444 (98.0)193 (98.0)10.84
A/A10 (2.2)8 (1.6)0.43 (0.15-1.21)9 (2.0)4 (2.0)1.15 (0.29-4.57)
Over-dominantG/G-A/A361 (79.3)402 (82.7)10.01352 (77.7)155 (78.7)10.12
A/G94 (20.7)84 (17.3)0.61 (0.41-0.89)101 (22.3)42 (21.3)0.70 (0.44-1.11)
Log-additive---0.60 (0.43-0.83)0.0018--0.78 (0.52-1.16)0.22
Table 7 Association of rs1137101 with hypertension and type 2 diabetes mellitus (hypertension and hypertension + type 2 diabetes mellitus)
ModelGenotypeHan, n = 892
Mongolian, n = 852
Control, n (%)
HTN with T2DM, n (%)
OR (95%CI)
P value
Control, n (%)
HTN with T2DM, n (%)
OR (95%CI)
P value
Co-dominantG/G312 (76.8)394 (81.1)10.034436 (66.6)151 (76.7)10.0067
A/G91 (22.4)84 (17.3)0.65 (0.46-0.92)202 (30.8)42 (21.3)0.54 (0.36-0.81)
A/A3 (0.7)8 (1.6)1.61 (0.41-6.28)17 (2.6)4 (2.0)0.55 (0.17-1.79)
DominantG/G312 (76.8)394 (81.1)10.026436 (66.6)151 (76.7)10.0016
A/G-A/A94 (23.1)92 (18.9)0.68 (0.49-0.96)219 (33.4)46 (23.4)0.54 (0.36-0.80)
RecessiveG/G-A/G403 (99.3)478 (98.3)10.39638 (97.4)193 (98.0)10.46
A/A3 (0.7)8 (1.6)1.77 (0.46-6.87)17 (2.6)4 (2.0)0.65 (0.20-2.11)
Over-dominantG/G-A/A315 (77.6)402 (82.7)10.012453 (69.2)155 (78.7)10.0028
A/G91 (22.4)84 (17.3)0.65 (0.46-0.91)202 (30.8)42 (21.3)0.55 (0.37-0.82)
Log-additive---0.75 (0.55-1.02)0.067--0.59 (0.41-0.84)0.0024