Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus

doi:10.4239/wjd.v9.i9.149

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Sep 15, 2018; 9(9): 149-156
Published online Sep 15, 2018. doi: 10.4239/wjd.v9.i9.149

Table 1 Number of hypoglycemia episodes and glycemic variability in experimental animals

Group	Control	IpMI	IaMI	GLP1pMI	GLP1aMI	GLP1pMI + IaMI
Hypoglycemia episodes (n)	0	5	3	1	2	1
Glycemic variability	4.48 ± 0.74	6.29 ± 0.9^a	5.57 ± 1.3	3.79 ± 0.65^a	3.60 ± 0.65^a	3.00 ± 0.42^a

^aP < 0.05, vs control group. Control: Rats with T2DM without therapy; IpMI: Rats treated with insulin prior to MI; IaMI: Rats treated with insulin after MI; GLP1pMI: Rats treated with GLP-1a prior to MI; GLP1aMI: Rats treated with GLP-1a after MI; GLP1pMI + IaMI: Rats treated with GLP-1a prior to MI and with insulin after MI.

Citation: Zykov VA, Tuchina TP, Lebedev DA, Krylova IB, Babenko AY, Kuleshova EV, Grineva EN, Bayramov AA, Galagudza MM. Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus. World J Diabetes 2018; 9(9): 149-156
URL: https://www.wjgnet.com/1948-9358/full/v9/i9/149.htm
DOI: https://dx.doi.org/10.4239/wjd.v9.i9.149