Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

Figure 1 Plasma biochemical change after coagonist treatment in streptozotocin-high-fat and db/db mice. A: Body weight; B: Fasting glucose; C: HbA1c; D: Fasting insulin; E: OGTT; F: ITT; G: Plasma triglycerides; H: Plasma cholesterol; I: Plasma FGF21; J: Plasma adiponectin; K: Plasma IL-6; L: Plasma TNF-α. Results are shown as mean ± SE (n = 10) for each group and P < 0.05 considered to be statistically significant. HFSTZ: Streptozotocin-high-fat; IPGTT: Intraperitoneal glucose tolerance test; ITT: Insulin tolerance test; HbA1c: Glycosylated hemoglobin; FGF21: Fibroblast growth factor 21; IL-6: Interleukin-6; TNF-α: Tumor necrosis alfa.