Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

Table 2 Plasma biochemistry, kidney weight, and kidney lipid changes after coagonist treatment in diet-induced obese mice (46-48 wk old)

Parameter/treatment	Vehicle control	Coagonist (150 µg/kg, sc)	Chow-fed control
Plasma creatinine (μmol/L)	36.2 ± 4.1	17.6 ± 5.4a	15.9 ± 2.3a
Plasma BUN (mg/dL)	48.1 ± 5.8	24.8 ± 2.3a	18.2 ± 4.2a
Urinary albumin (μg/d)	210.7 ± 15.4	71.3 ± 5.8a	50.9 ± 4.7a
Renal triglycerides (μg/mg of protein)	64.8 ± 5.8	27.8 ± 8.4a	25.3 ± 2.8a
Renal cholesterol (μg/mg of protein)	22.5 ± 5.4	12.6 ± 3.3a	5.7 ± 2.1a
Kidney weight (mg)	541.2 ± 46.8	387.4 ± 14.8a	210.3 ± 42.4a

Data are shown as the mean ± SE.

^aP < 0.05, vs vehicle control. BUN: Blood urea nitrogen.