Effects of glucose-lowering agents on cardiorespiratory fitness

doi:10.4239/wjd.v9.i12.230

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Dec 15, 2018; 9(12): 230-238
Published online Dec 15, 2018. doi: 10.4239/wjd.v9.i12.230

Table 4 Effects of sodium–glucose cotransporter 2 inihibitors on cardiorespiratory fitness in patients with type 2 diabetes

Ref.	Study design	Subjects	SGLT2 inhibitors dose	Results
Núñez et al[45], 2017	Before-after study	19 patients with type 2 diabetes and heart failure	Empagliflozin, 10 mg/d	VO_2peak↑, ventilatory efficiency during exercise↑, 6-minute walking distance↑, ↓antigen carbohydrate 125
		Age (median): 72 yr
		Sex: 14 men and 5 women
		BMI: 30.6 ± 5.5 kg/m²
		HbA1c: No description
Carbone et al[46], 2018	Before-after study	15 patients with type 2 diabetes and heart failure	Empagliflozin, 10 mg/d	VO_2peak↑ in patients using loop diuretics
		Age (median): 60 yr		VO_2peak↓ in patients without loop diuretics
		Sex: 7 men and 8 women
		BMI (median): 34 kg/m²
		HbA1c (median): 7.8%

SGLT2: Sodium–glucose cotransporter 2; BMI: Body mass index; HbA1c: Hemoglobin A1c; VO₂: Oxygen consumption.

Citation: Hamasaki H. Effects of glucose-lowering agents on cardiorespiratory fitness. World J Diabetes 2018; 9(12): 230-238
URL: https://www.wjgnet.com/1948-9358/full/v9/i12/230.htm
DOI: https://dx.doi.org/10.4239/wjd.v9.i12.230