Topical application of platelet-rich plasma for diabetic foot ulcers: A systematic review

Table 1 Study demographics

	Mohammadi et al[6] 2017	Ahmed et al[7] 2017	Perez-Zabala et al[8] 2016	Saad et al[9] 2011	Kakagia et al[10] 2007	Driver et al[11] 2006	Li et al[12] 2015	Saldalam-acchia et al[13] 2004	Motolese et al[14] 2015	Shan et al[15] 2013	Kontopodis et al[16] 2016	Weighted (mean ± SD)[6]	P-value (PRP vs control)
Type of Study	PU	RP	CS	RP	RP	RDBP	RP	RP	PU	PU	RU	N/A	N/A
Level of evidence	III	II	IV	II	II	II	II	II	III	III	III	N/A	N/A
No. patients
PRP	70	28	2	12	17	19	59	7	15	21	72	29.3 ± 25.4	0.104
Control	N/A	28	N/A	12	N/A	21	58	7	N/A	N/A	N/A	25.2 ± 20.0
Age (mean ± SD, yr)
PRP	53.8 ± 10.6	43.2 ± 18.2	65.5 ± 2.1	NR	57.0 ± 12.0	58.3 ± 9.7	61.4 ± 13.1	61.1 ± 9.4	52.3 ± 11.3	66.5 ± 10.8	65	58.4 ± 7.2	0.678
Control	N/A	49.8 ± 15.4	N/A	NR	N/A	55.9 ± 8.1	64.1 ± 9.4	58.1 ± 7.8	N/A	N/A	N/A	58.7 ± 5.9
Female gender, n (%)
PRP	12 (17.1)	8 (28.6)	0 (0.0)	NR	NR	3 (15.8)	22 (37.3)	4 (57.1)	11 (73.3)	13 (61.9)	14 (19.4)	29.70%	0.407
Control	N/A	10 (35.7)	N/A	NR	N/A	5 (23.8)	20 (34.5)	4 (57.1)	N/A	N/A	N/A	35.10%
Duration of diabetes (mean ± SD, yr)
PRP	16.2 ± 7.9	NR	23.5 ± 13.4	NR	NR	NR	7.50	16.3 ± 7.9	38.20	6.8 ± 6.7	NR	14.1 ± 11.6	0.048
Control	N/A	NR	N/A	NR	N/A	NR	10.00	19.7 ± 9.9	N/A	N/A	N/A	11.0 ± 6.9
Duration of ulcer (mean ± SD, wk)
PRP	19.6 ± 4.7	12.5 ± 1.0	28.3 ± 9.5	NR	19.0 ± 8.0	NR	4.28	NR	NR	10.1 ± 12.0	NR	13.0 ± 8.4	< 0.001
Control	N/A	11.5 ± 2.8	N/A	NR	N/A	NR	3.30	NR	N/A	N/A	N/A	6.0 ± 5.8
HbA1c (mean ± SD)
PRP	6.2 ± 0.7	7.0 ± 0.5	9.4 ± 3.3	NR	8.1 ± 2.8	7.8 ± 1.5	9.8 ± 3.1	9.5 ± 1.7	NR	9.1 ± 2.2	NR	7.9 ± 1.3	< 0.001
Control	N/A	6.9 ± 0.6	N/A	NR	N/A	8.1 ± 1.8	9.80	8.8 ± 1.7	N/A	N/A	N/A	8.7 ± 1.2
Ulcer area (mean ± SD, cm2)
PRP	6.11 ± 4.37	6.24 ± 0.9	10.25	NR	28.4 ± 13.6	3.4 ± 4.5	4.10	27.3 ± 15.6	13.92	14.0 ± 32.3	4.1 ± 3.9	7.7 ± 9.3	< 0.001
Control	N/A	5.72 ± 0.8	N/A	NR	N/A	3.6 ± 4.0	2.90	17.0 ± 8.9	N/A	N/A	N/A	4.6 ± 6.6

N/A: Not applicable; PU: Prospective uncontrolled; RP: Randomized prospective; CS: Case series; RDBP: Randomized double-blind prospective; RU: Retrospective uncontrolled; NR: Not recorded; PRP: Platelet-rich plasma.